Use a unified interface to numerous Blast systems

Unlike other Blast servers available on the Internet, each offering a different interface, KoriBlast offers a single graphical interface to schedule and launch sequence comparisons with Blast systems available online and locally. It is thus very easy to schedule Blast searches using the NCBI Blast server (1), the EBI Wu-Blast server, a WwwBlast server (2), a Local Blast (3) or a Grid-based Blast system (4).

Compare results in unexpected ways

KoriBlast enables you to compare your results in order to discover common, new or deleted hits in your data sets. In addition, you can reuse your strategies at regular intervals over time. This makes it very easy for you to compare your sequences with the various versions of a database to discover the new sequences related to your search subject. All done in just a single mouse click.

When examining the results of sequence searches, KoriBlast enables you to select all or part of hit sequences, to extract and display them within the analyse viewers (see below), or to schedule a new search job immediately. You may also retrieve these sequences as Fasta files or view their complete original database entries in your web browser.

Analyze all data visually

Instead of studying a long text report, KoriBlast features a single analysis window integrating a set of visualization interfaces adapted to exploring search results. Very simple to learn and use, these interfaces are suitable for rapidly examining hit tables, sequence alignments (by pairs and in multiples), distance trees and annotations presented in context on databases sequences or even for locating potentially functional regions. Displays are created using all or user-seleted hits.

In the context of a taxonomic survey or an inspection of 3D structure data, KoriBlast features an interactive taxonomic viewer and a 3D structure viewer, respectively.

Discover information only relevant to your research

In order to locate pertinent information, you can query all the data available in KoriBlast. This enables quick and easy identification of the hits meeting the criteria you have determined within a set of search results. These criteria apply to values calculated by Blast (E-values, (bit-) scores, sequence identities/similarities, alignment coordinates, etc.) and to data from databases (sequence descriptions, features and taxonomic data). This way, you can filter out hits satisfying (or not) a wide range of criteria.

The following picture shows you how easy it is to create a filter used in the context of a comparative genomics study: when comparing full genomes, how to retain only the proteins that are conserved and well-known within a genome of interest ? We are going to apply the filter on a set of 1566 proteins just within a few mouse clicks...

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(1) as well as the "traditional" databases (GenBank, SwissProt, etc), KoriBlast will also enable you to access numerous thematic databases offered by the NCBI.
(2) you probably have a server like this in your laboratory. If this is this case, Koriblast can use it directly.
(3) KoriBlast comes with NCBI Blast software: You can therefore use Blast on your computer with your personal sequence databases and/or a local copy of public sequence databases (SwissProt, Genbank, etc.) as required.
(4) KoriBlast is ready to communicate with a high-throughput Blast system driven by the Sun Grig Engine (SGE). If you have such a system within your Institute/Company, then KoriBlast will be able to use it.