RNA-seq co-expression network analysis reveals anxiolytic behavior of mice with Efnb2 knockout in parvalbumin+ neurons

RNA-seq co-expression network analysis reveals anxiolytic behavior of mice with Efnb2 knockout in parvalbumin+ neurons

Nervousness issues are the most typical psychiatric issues, and the change within the exercise of the prefrontal cortex (PFC) is taken into account because the underlying pathological mechanism. Parvalbumin-expressing (PV+) inhibition contributes to the general exercise of the PFC. Nonetheless, the molecular mechanism underlying the excitation-inhibition imbalance of PV+ neurons within the PFC is unknown. […]