Dexamethasone transiently enhances transgene expression in the liver when administered at late phase post long term AAV transduction

Dexamethasone transiently enhances transgene expression in the liver when administered at late phase post long term AAV transduction

Glucocorticoids have anti-inflammatory and immunosuppressive features and have generally been used for stopping liver toxicity after the systemic software of a excessive dose of adeno-associated virus (AAV) vector for gene remedy. Medical research have reported that glucocorticoids have rescued Issue IX (FIX) expression in hemophilia B sufferers who confirmed a lowered FIX expression at 6 […]