Diurnal variability of glucose tetrasaccharide (Glc 4) excretion in patients with glycogen storage disease type III

Diurnal variability of glucose tetrasaccharide (Glc 4) excretion in patients with glycogen storage disease type III

The urinary glucose tetrasaccharide, Glcα1-6Glcα1-4Glcα1-4Glc (Glc4), is a glycogen restrict dextrin that’s elevated in sufferers with glycogen storage illness (GSD) kind III. We evaluated the potential of raw cornstarch remedy to intervene with Glc4 monitoring, by measuring the diurnal variability of Glc4 excretion in sufferers with GSD III. Voids had been collected at dwelling over 24 hours, saved at 4°C and frozen inside 48 hours. Glc4 was analyzed utilizing liquid chromatography-tandem mass spectrometry and normalized to creatinine.
Topics with GSD III (median age: 13.5 years, vary: 3.7-62; n = 18) accomplished a number of 24-hour urine assortment, and 28/36 collections had been accepted for evaluation. Glc4 was elevated in 16/18 topics (median: 13 mmol/mol creatinine, vary: 2-75, reference vary: <3). In collections with elevated Glc4 (23/28), two-thirds (15/23) had low diurnal variability in Glc4 excretion (coefficient of variation [CV%] <25). The diurnal variability was considerably correlated with the Glc4 focus (Pearson R = .644, P < .05), however not with the dose of raw cornstarch. Excessive intraday variability (>25%) was not constantly noticed in repeat collections by the identical topic.

 The extent and variability of Glc4 excretion relative to creatinine was not correlated with cornstarch dose. A majority of collections confirmed low variability over 24 hours. These findings assist using single time-point collections to guage Glc4 in sufferers with GSD III handled with cornstarch. Nonetheless, repeat sampling over quick time-periods will present essentially the most correct evaluation of Glc4 excretion, as intraday variability could also be elevated in sufferers with excessive Glc4 excretion.

An Proof for a Novel Antiviral Mechanism: Modulating Results of Arg-Glc Maillard Response Merchandise on the Part Transition of Multilamellar Vesicles

Maillard response merchandise (MRPs) of protein, amino acids, and lowering sugars from many meals and aqueous extracts of herbs are discovered to have numerous bioactivities, together with antiviral results. A speculation was proposed that their antiviral exercise is because of the interplay with the mobile membrane. Aiming to estimate the doable actions of MRPs on phospholipid bilayers, the Arg-Glc MRPs had been ready by boiling the pre-mixed answer of arginine and glucose for 60 min at 100°C after which examined at a collection of concentrations for his or her results on the part transition of MeDOPE multilamellar vesicles (MLVs), for the primary time, through the use of differential scanning calorimetry (DSC) and temperature-resolved small-angle X-ray scattering (SAXS).

Arg-Glc MRPs inhibited the lamellar gel-liquid crystal (L βL α), lamellar liquid crystal-cubic (L αQ II), and lamellar liquid crystal-inverted hexagonal (L αH II) part transitions at low focus (molar ratio of lipid vs. MRPs was 100:1 or 100:2), however promoted all three transitions at medium focus (100:5). At excessive focus (10:1), the MRPs exhibited inhibitory impact once more. The fusion peptide from simian immunodeficiency virus (SIV) induces membrane fusion by selling the formation of a non-lamellar part, e.g., cubic (Q II) part, and inhibiting the transition to H II.

Arg-Glc MRPs, at low focus, stabilized the lamellar construction of SIV peptide containing lipid bilayers, however facilitated the formation of non-lamellar phases at medium focus (100:5). The concentration-dependent exercise of MRPs upon lipid part transition indiciates a possible function in modulating some membrane-related organic occasions, e.g., viral membrane fusion.

Diurnal variability of glucose tetrasaccharide (Glc 4) excretion in patients with glycogen storage disease type III

The bioavailability and excretion of an antitussive compound IAsp-N-Glc in rats by validated UPLC-MS/MS strategies

IAsp-N-Glc is a possible antitussive agent that’s first reported to be remoted from Ginkgo Semen, however the bioavailability and excretion of IAsp-N-Glc are unknown. Subsequently, we carried out our research to acquire the bioavailability and excretion profiles of IAsp-N-Glc in rats. Fast, particular, and dependable quantification strategies for the measurement of IAsp-N-Glc in rat plasma and fecal samples through the use of ultra-high-performance liquid chromatography coupled with triple quadrupole mass spectrometry had been developed and validated. A C18 column was used for the separation of IAsp-N-Glc and inside requirements, and water (containing 0.1% formic acid) and acetonitrile had been chosen because the cellular part for the separation within the flow-gradient mode.

Within the ranges of 37.5-7500 ng/mL and 120-30000 ng/mL, the calibration curves of IAsp-N-Glc exhibited passable linearity for plasma and fecal samples with every linear correlation coefficient greater than 0.99, respectively. The strategies had been reproducible and dependable. The analytes had been steady, and no obvious matrix results had been noticed. The bioanalytical strategies had been efficiently used to check the pharmacokinetics and excretion of IAsp-N-Glc in rats. Oral administration of IAsp-N-Glc exhibited a low absolute oral bioavailability (1.83±0.09%), and 59.63±6.29% of IAsp-N-Glc was excreted in feces. This report is the primary to explain the bioavailability and excretion of IAsp-N-Glc in rats and can lay the inspiration for the in-depth research and drug improvement of IAsp-N-Glc.

Si-Miao-Yong-An decoction preserves cardiac operate and regulates GLC/AMPK/NF-κB and GLC/PPARα/PGC-1α pathways in diabetic mice

Streptozotocin-induced diabetic mice had been fed intragastrically with SMYA daily for 15 weeks. Cardiac operate was assessed by echocardiograph. Histopathological alterations within the coronary heart had been decided by hematoxylin/eosin, wheat germ agglutinin, Masson’s trichrome, Terminal dUTP nick end-labeling, Oil pink O staining, and transmission electron microscopy. The potential involvements of GLC/AMPK/NF-κB and GLC/PPARα/PGC-1α signaling pathways had been investigated by western blot and/or immunohistochemical staining.

Therapy of diabetic mice with SMYA improved insulin sensitivity, and attenuated the will increase of water consumption, meals consumption, blood glucose, and serum GLC. Moreover, SMYA ameliorated cardiac systolic and diastolic features, suppressed the myocardial hypertrophy, fibrosis, apoptosis, irritation, and lipid accumulation in addition to preserved the myofilaments association and mitochondrial integrity.

100 BP DNA LADDER, 500UL PER KIT

M-DNA-100BP 1/pk
EUR 87.6
Description: Bioscience Mol Bio; DNA Ladder

50 kb large-Range DNA ladder

308-025 250 µg
EUR 144

Azura PureView 1 Kb DNA Ladder - 100 Lanes

AZ-1101 100 Lanes
EUR 140.4

Azura PureView 1 Kb DNA Ladder - 500 Lanes

AZ-1105 500 Lanes
EUR 277.2

Azura PureView 1 Kb DNA Ladder - 1000 Lanes

AZ-1105-2 1000 Lanes
EUR 326.4

ACTGene? DNA Marker, 1 kb Ladder, 13 Fragments, 100 loads

ACT-IDMWD1 each
EUR 178.8

ACTGene? DNA Marker, 1 kb Plus Ladder, 19 Fragments, 100 loads

ACT-IDMWD2 each
EUR 178.8

100bp DNA ladder

9K-004-0002 0.5ml
EUR 260.98

OneMark B DNA Ladder (ready-to-use, 250-1000 kb)

DM110-0100 600 µl
EUR 75.6

XXL DNA ladder ready-to use (2kb - 25 kb, 2 dyes)

300007 50µg/500µl
EUR 84

XXL DNA ladder ready-to use (2kb - 25 kb, 2 dyes)

300008 5x50 µg
EUR 253.2

One-for-all DNA ladder ready-to-use (100bp - 10 kb, 1 dye)

300005 86µg/500µl
EUR 84

One-for-all DNA ladder ready-to-use (100bp - 10 kb, 1 dye)

300006 5x86 µg
EUR 253.2

One-for-all DNA ladder ready-to-use (100bp - 10 kb, 1 dye)

300006L 10x86 µg
EUR 465.6

One-for-all DNA ladder ready-to-use (100bp - 10 kb, 1 dye)

300006XL 20x86 µg
EUR 894

100 bp DNA Ladder

MD104-01 250 μl
EUR 132

100 bp DNA Ladder

MD104-02 500 μl
EUR 139.2

iVDye 50bp DNA Ladder

V1001-001 1ml
EUR 218.4

iVDye 50bp DNA Ladder

V1001-025 250ul
EUR 105.6

iVDye 50bp DNA Ladder

V1001-100 4x250ul
EUR 230.4

iVDye 50bp DNA Ladder

V1001-250 10X250ul
EUR 422.4

iVDye 100bp DNA Ladder

V1002-001 1ml
EUR 199.2

iVDye 100bp DNA Ladder

V1002-025 250ul
EUR 96

iVDye 100bp DNA Ladder

V1002-100 4x250ul
EUR 195.6

iVDye 100bp DNA Ladder

V1002-250 10X250ul
EUR 378

iVDye 1Kb DNA Ladder

V1003-001 1ml
EUR 148.8

iVDye 1Kb DNA Ladder

V1003-025 250ul
EUR 91.2

iVDye 1Kb DNA Ladder

V1003-100 4x250ul
EUR 157.2

iVDye 1Kb DNA Ladder

V1003-250 10x250ul
EUR 273.6

iVDye 1Kb DNA Ladder

V1003-500 20x250ul
EUR 457.2

100 bp DNA Ladder

M1158-500 each
EUR 333.6

Human Genomic DNA 

X11000
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Human Brain Genomic DNA  

X11001
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  • 10 µg
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Star 1kb DNA Ladder Express

BT10701 500µl
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Description: High purity buffer for various PCR applications.

100 bp Ladder DNA Marker

FYD002-500UL 30 µg/ 500 µl Ask for price

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Apoptotic DNA Ladder Isolation Kit

K2045-50 50 assays
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K170-50 each
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DNA Methylation Antibody Panel Pack I

C20000
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  • EUR 270.60
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Image Green? 1 kb DNA Marker

M1156-500 each
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DNA High Binding Solution

R-1103
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  • 30 ml
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Star 100 bp DNA Ladder Express

BA01302 500µl
EUR 96
Description: High purity buffer for various PCR applications.

Enhanced Apoptotic DNA Ladder Detection Kit

K2202-50 50 assays
EUR 568.8

Quick Apoptotic DNA Ladder Detection Kit

K2194-50 50 assays
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Quick Apoptotic DNA Ladder Detection Kit

K120-50 each
EUR 548.4

Enhanced Apoptotic DNA Ladder Detection Kit

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Wide range 100 bp DNA Ladder

M1192-500 each
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Methylamp 96 DNA Modification Kit 

P-1008
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  • EUR 253.00
  • 96 Samples
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100 bp-10 Kb Wide Range DNA Logical Marker, Original Form

M103O-1 100loading, 100prep
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DNA Polymerase Enzyme (4 kb)

abx071004-10kU 10 kU
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DNA Polymerase Enzyme (4 kb)

abx071004-3kU 3 kU
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DNA Polymerase Enzyme (4 kb)

abx071004-500U 500 U
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DNA Polymerase Enzyme (4 kb)

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DNA Polymerase Enzyme (15 kb)

abx071012-250U 250 U
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abx071012-3kU 3 kU
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DNA Polymerase Enzyme (15 kb)

abx071012-500U 500 U
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DNA Concentrator Kit 

P-1006
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100 bp DNA Ladder Plus, ready-to-use, 50 ug, 0.5 ug per lane

Z6030001-1 100 lanes
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1.5 kb to 48.5 kb High Range DNA Marker

E255 150ug, 150ug
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100 bp-10 Kb Wide Range DNA Logical Marker, Ready-to-use

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Renilla Luciferase Assay Kit 2.0

30082-1 150AS
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Description: Minimum order quantity: 1 unit of 150AS

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30085-1 150AS
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Description: Minimum order quantity: 1 unit of 150AS

1000bp/1kb DNA ladder (no loading dye)

305-005 50µg/250µl
EUR 60

1000bp/1kb DNA ladder (no loading dye)

305-025 5x50µg
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20 bp TinyOrange DNA Ladder (105ng/µl)

309-005 500 µl
EUR 129.6

20 bp TinyOrange DNA Ladder (105ng/µl)

309-025 5x500µl
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1Kb Plus DNA Ladder, Ready-to-use

9K-004-0001 0.5ml
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Azura PureView 250bp DNA Ladder - 100 Lanes

AZ-1121 100 Lanes
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AZ-1125 500 Lanes
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Azura PureView 250bp DNA Ladder - 1000 Lanes

AZ-1125-2 1000 Lanes
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Azura PureView 100bp DNA Ladder - 100 Lanes

AZ-1131 100 Lanes
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AZ-1135 500 Lanes
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AZ-1135-2 1000 Lanes
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Azura PureView 50bp DNA Ladder - 100 Lanes

AZ-1151 100 Lanes
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Azura PureView 50bp DNA Ladder - 500 Lanes

AZ-1155 500 Lanes
EUR 277.2

Azura PureView 50bp DNA Ladder - 1000 Lanes

AZ-1155-2 1000 Lanes
EUR 326.4

100 bp DNA Ladder 500ul per k

AXY1014 EACH
EUR 145.92

Methylamp DNA Modification Kit 

P-1001
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  • EUR 149.60
  • EUR 259.60
  • 80 Reactions
  • 40 Reactions
  • 80 Reactions

pGreenFire1-NF-kB (plasmid)

TR012PA-1 10 ug
EUR 943.2

pGreenFire1-NF-kB (virus)

TR012VA-1 >2 x 10^6 IFUs
EUR 943.2

DNA Polymerase (6 kb / min) Enzyme

abx071002-3kU 3 kU
EUR 360

DNA Polymerase (6 kb / min) Enzyme

abx071002-500U 500 U
EUR 226.8

Methylamp Universal Methylated DNA Kit 

P-1011
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  • EUR 442.20
  • 20 Modifications
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FitAmp Circulating DNA Quantification Kit 

P-1012
  • EUR 595.92
  • EUR 217.80
  • EUR 387.20
  • 96 Assays
  • 48 Assays
  • 96 Assays 

100bp plus DNA ladder (blue, ready-to-use)

304-105 50µg/500µl
EUR 60

100bp plus DNA ladder (blue, ready-to-use)

304-125 5x50 µg
EUR 144

1000bp/1kb DNA ladder (blue, ready-to-use)

305-105 50µg/500µl
EUR 60

1000bp/1kb DNA ladder (blue, ready-to-use)

305-105L 10x50 µg Ask for price

1000bp/1kb DNA ladder (blue, ready-to-use)

305-105XL 20x50 µg Ask for price

1000bp/1kb DNA ladder (blue, ready-to-use)

305-125 5x50 µg
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FitAmp Plasma/Serum DNA Isolation Kit 

P-1004
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  • EUR 253.00
  • 100 Samples
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  • 100 Samples

Methylamp One-Step DNA Modification Kit 

P-1010
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  • EUR 148.50
  • EUR 253.00
  • 80 Samples
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Supercoiled pHOT-1 DNA

TG2030-1 25 ug
EUR 295.2

Relaxed pHOT-1 DNA

TG2035-1 25 ug
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FitAmp General Tissue Section DNA Isolation Kit 

P-1003
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  • EUR 253.00
  • EUR 490.60
  • 100 Samples
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  • 100 Samples

FitAmp Paraffin Tissue Section DNA Isolation Kit 

P-1009
  • EUR 702.06
  • EUR 239.80
  • EUR 454.30
  • 100 Samples
  • 50 Samples
  • 100 Samples

MiTeGen Cryo-EM Puck, Generation 2.0 Puck Qty 1

M-CEMG2-1 1 PUCK
EUR 112
Description: MiTeGen Cryo-EM Puck, Generation 2.0 Puck Qty 1FREE Custom puck Barcoding and Engraving (example: ABC-001 to ABC-010) (M-CEMG2-Barcoding)FREE Custom puck color selection - Choose any combination of the following colors: Red, Blue, Purple, Grey, Black, Gold ,Green, Violet, Brown, Orange (M-CEMG2-CustomColor)

EpiQuik DNA Methyltransferase (DNMT) Activity/Inhibition Assay Kit 

P-3001
  • EUR 1050.06
  • EUR 424.60
  • EUR 712.80
  • 96 Assays
  • 48 Assays
  • 96 Assays

50bp DNA ladder (no loading dye) (50bp - 1000 bp)

300009 50µg/250µl
EUR 60

50bp DNA ladder (no loading dye) (50bp - 1000 bp)

300010 5x50 µg
EUR 144

Anti-NF-kB p65/RELA Antibody

A00284-1 100ug/vial
EUR 400.8

BLIV 2.0 Reporter: CMV-Luciferase-EF1a-copGFP Lentivector Plasmid

BLIV511PA-1 10 ug
EUR 963.6

DiscoveryProbe? DNA Damage/DNA Repair Library

L1033-.1 100 uL/well(10 mM solution)
EUR 4666.8

100-3000 bp DNA Rainbow Ladder PRODUCT (ready-to-use)

307-105 50µg/500µl
EUR 60

100-3000 bp DNA Rainbow Ladder PRODUCT (ready-to-use)

307-105L 10x50 µg Ask for price

100-3000 bp DNA Rainbow Ladder PRODUCT (ready-to-use)

307-105XL 20x50 µg Ask for price

100-3000 bp DNA Rainbow Ladder PRODUCT (ready-to-use)

307-125 5x50µg
EUR 144

OneMark 100 DNA Ladder (ready-to-use, 100-3000 bp)

DM101-0100 600 µl
EUR 75.6

ACTGene? DNA Marker, 100 bp Ladder, 11 Fragments, 100 loads

ACT-IDMWD100 each
EUR 178.8

DNA-Fect

DF37100-1 1 ml
EUR 418.8

DNA-Fect293

DF37293-1 1 ml
EUR 349.2

DNA Polymerase (with 2.5 mM dNTPs) (1-2 kb / min) Enzyme

abx071005-10kU 10 kU
EUR 610.8

DNA Polymerase (with 2.5 mM dNTPs) (1-2 kb / min) Enzyme

abx071005-3kU 3 kU
EUR 326.4

DNA Polymerase (with 2.5 mM dNTPs) (1-2 kb / min) Enzyme

abx071005-500U 500 U
EUR 226.8

BLIV 2.0 Reporter: CMV-Luciferase-EF1a-copGFP Pre-packaged Virus

BLIV511VA-1 >2 x10^6 IFUs
EUR 963.6

NF-kB/Jurkat/GFP Transcriptional Reporter Cell Line

TR850A-1 >2 x 10^6 cells
EUR 4611.6

DNA Polymerase (with 2.5 mM dNTPs) (4 kb) Enzyme

abx071003-3kU 3 kU
EUR 410.4

DNA Polymerase (with 2.5 mM dNTPs) (4 kb) Enzyme

abx071003-500U 500 U
EUR 243.6

DNA Polymerase (with 2.5 mM dNTPs) (15 kb) Enzyme

abx071013-250U 250 U
EUR 276

DNA Polymerase (with 2.5 mM dNTPs) (15 kb) Enzyme

abx071013-3kU 3 kU
EUR 878.4

DNA Polymerase (with 2.5 mM dNTPs) (15 kb) Enzyme

abx071013-500U 500 U
EUR 326.4

50bp DNA ladder ready-to-use (50bp - 1500 bp, 2 dyes)

300003 50µg/500µl
EUR 84

50bp DNA ladder ready-to-use (50bp - 1500 bp, 2 dyes)

300003L 10x50 µg Ask for price

50bp DNA ladder ready-to-use (50bp - 1500 bp, 2 dyes)

300003XL 20x50 µg Ask for price

50bp DNA ladder ready-to-use (50bp - 1500 bp, 2 dyes)

300004 5x50 µg
EUR 253.2

Kinetoplast DNA (catenated)

TG2013-1 25 ug
EUR 321.6

Human Genomic DNA 

X11000-1 0.2 ml
EUR 235.4

DNA Cleared Plasma

DCP100A-1 100 ml
EUR 417

BLIV 2.0 Reporter: MSCV-Luciferase-EF1a-copGFP-T2A-Puro Lentivector Plasmid

BLIV713PA-1 10 ug
EUR 963.6

NF-kB/293/GFP-Luc Transcriptional Reporter Cell Line

TR860A-1 >2 x 10^6 cells
EUR 3915.6

BLIV 2.0 Reporter: MSCV-Luciferase-EF1a-copGFP-T2A-Puro Pre-packaged Virus

BLIV713VA-1 >2 x10^6 IFUs
EUR 963.6

WSE-7020 EzProtein Ladder

2332346 1unit
EUR 339.6
Description: Pr ot ei n col or ed M ar k er

KB-5246

HY-19081 5mg
EUR 3370.8

Anti-DNA-PKCS Antibody

A00645-1 100ul
EUR 476.4
Description: Rabbit Polyclonal Antibody for DNA-PKCS Antibody (PRKDC) detection.tested for WB in Human, Mouse.

E. coli DNA Gyrase

TG2000G-1 100 units
EUR 388.8

S. aureus DNA Gyrase

TG2000GSA-1 100 units
EUR 483.6

Linear Kinetoplast DNA Marker

TG2018-1 10 ug
EUR 214.8

Decatenated Kinetoplast DNA Marker

TG2020-1 10 ug
EUR 228

Relaxed pRYG DNA Marker

TG2025-1 10 ug
EUR 321.6

Linear pRYG DNA Marker

TG2028-1 10 ug
EUR 214.8

Human TDP2 DNA Substrate

TG2038-1 10 ug
EUR 496.8

Human Brain Genomic DNA  

X11001-1 10 ul
EUR 77

T4 DNA Ligase Buffer

9102-1 each
EUR 105.6

AAVS1 Safe Harbor Targeting Vector 2.0 - All-Purpose Donor (AAVS1-SA-puro-MCS)

GE620A-1 10 ug
EUR 1443.6

DNA Concentrator Kit 

P-1006-1 50 Samples
EUR 90.2

TDP1 Human, Tyrosyl-DNA Phosphodiesterase 1 Human Recombinant Protein, Sf9

PROTQ9NUW8-1 Regular: 5ug
EUR 380.4
Description: TDP1 Human Recombinant produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 617 amino acids (1-608) and having a molecular mass of 69.5kDa (Molecular size on SDS-PAGE will appear at approximately 50-70kDa). TDP1 is fused to 9 amino acid His-Tag at C-terminus and purified by proprietary chromatographic techniques. 

Oxalic Acid Solution (2.0%)

OQB125 125 ml
EUR 86.4

Oxalic Acid Solution (2.0%)

OQB500 500 ml
EUR 110.4

Oxalic Acid Solution (2.0%)

OQB999 1000 ml
EUR 140.4

Anti-DNA pol beta Antibody

A01946-1 100ul
EUR 476.4
Description: Rabbit Polyclonal Antibody for DNA pol beta Antibody (POLB) detection.tested for WB in Human, Mouse, Rat.

Lastly, SMYA downregulated the expressions of GCGR, PGC-1α, PPARα and the phosphorylation of NF-κB, in addition to upregulated the phosphorylation of AMPK within the hearts of diabetic mice.

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