The glycan role in the glycopeptide immunogenicity revealed by atomistic simulations and spectroscopic experiments on the multiple sclerosis biomarker CSF114(Glc).

The glycan role in the glycopeptide immunogenicity revealed by atomistic simulations and spectroscopic experiments on the multiple sclerosis biomarker CSF114(Glc).

Glycoproteins are sometimes acknowledged as not-self molecules by antibodies triggering the onset of extreme autoimmune illnesses resembling A number of Sclerosis (MS). Thus, the event of antigen-mimicking biomarkers represents a sexy technique for an early analysis of the illness. An instance is the artificial glycopeptide CSF114(Glc), which was designed and examined as MS biomarker and whose scientific utility was restricted by its diminished capability to detect autoantibodies in MS sufferers. Within the try to enhance the efficacy of CSF114(Glc), we’ve characterised all of the occasions resulting in the ultimate binding of the biomarker to the autoantibody utilizing atomistic simulations, ESR and NMR experiments. The glycosydic moiety performs a major function in the entire course of.

Particularly, in an setting mimicking that used within the scientific checks the glycopeptide assumes a α-helix construction that’s useful for the interplay with the antibody. On this conformation CSF114(Glc) binds the monoclonal antibody mAb8-18C5 equally to the myelin oligodendrocyte glycoprotein MOG, which is a identified MS auto-antigen, thus explaining its diagnostic exercise. Our examine provides new molecular bases to design more practical biomarkers and offers a most legitimate protocol to analyze different methods the place the setting impact is determinant for the organic exercise.

The current examine was carried out to look at the dissipation sample of triazophos on capsicum and danger evaluation of its residues on human beings and to recommend a ready interval for the protection of customers. Following two functions of triazophos (Truzo 40 EC) at 500 and 1000 g a.i. ha(-1), the typical preliminary deposits had been discovered to be 3.61 and 6.26 mg kg(-1), respectively. These residues dissipated beneath the restrict of quantification (LOQ) of 0.05 mg kg(-1) in 10 and 15 days on the beneficial and double the beneficial dosages, respectively. The calculated values of half-life had been 2.31 and a couple of.

14 days at beneficial and double the beneficial dosages, respectively. Theoretical most residue contribution (TMRC) values had been discovered to be 28.eight and 41.6 μg individual(-1) day(-1) at 500 and 1000 g a.i. ha(-1), respectively, and located to be beneath the utmost permissible consumption on capsicum fruit on the seventh day. Subsequently, a ready interval of seven days is recommended for consumption of capsicum sprayed with triazophos on the beneficial dosages.

Preliminary examine on utility of urine amino acids profiling for monitoring of renal tubular damage utilizing GLC-MS.

The early analysis of the nephrotoxic impact of xenobiotics and medicines remains to be an unsolved drawback. Current research recommend a correlation between the nephrotoxic exercise of xenobiotics and elevated focus of amino acids in urine. The introduced examine was targeted on the applying of GLC-MS methodology for amino acids profiling in human urine as a noninvasive methodology for monitoring of kidney situation and tubular damage degree.
The analytic methodology relies on the conversion of the amino acids current within the pattern to tert-butyldimethylsilyl (TBDMS) derivatives and their evaluation by gas-liquid chromatography-mass spectrometry (GLC-MS). The process of urine pattern preparation for chromatographic evaluation was optimized. CSF114(Glc) is an artificial glucopeptide detecting in vitro MS-specific auto-antibodies, and it’s actively utilized in diagnostics and analysis to observe and quantify MS-associated Ig ranges.
The presence of 12 amino acids in a lot of the examined wholesome human urine samples was detected. The numerous variations within the ranges of specific amino acids between sufferers with tubular damage and wholesome controls had been discovered, particularly for lysine, valine, serine, alanine and leucine. We discovered that this strategy based mostly on GLC-MS detection can be utilized in nephrotoxicity research for urine amino acids monitoring in publicity to xenobiotics and medicines.
The glycan role in the glycopeptide immunogenicity revealed by atomistic simulations and spectroscopic experiments on the multiple sclerosis biomarker CSF114(Glc).

A easy methodology for isolation and purification of DIBOA-Glc from Tripsacum dactyloides.

Naturally occurring benzoxazinones (Bx) are a extremely reactive class of compounds which have obtained specific consideration prior to now a number of many years. Lately, we recognized 2-β-D-glucopyranosyloxy-4-hydroxy-1,4-benzoxazin-3-one (DIBOA-Glc) because the compound current within the roots of Japanese gamagrass {Tripsacum dactyloides (L.)} accountable for atrazine degradation. Nonetheless, characterization of the DIBOA-Glc/atrazine degradation response has been restricted on account of difficulties achieve ample portions of purified DIBOA-Glc.

The target of the examine was to develop a easy purification and isolation methodology for acquiring bulk portions of extremely purified DIBOA-Glc. T. dactyloides roots had been extracted with 90% aqueous methanol, and the crude extract was fractionated utilizing an HPLC geared up with a C8 semi-prep column and fraction collector. UHPLC-DAD-MS/MS was used to verify the identification of DIBOA-Glc within the fractions collected. Evaluation by 13C and 1H NMR and DAD indicated that 542 mg of DIBOA-Glc with a purity of>> 99% was obtained.

The reactivity of the DIBOA-Glc was confirmed in a 16 hour assay with atrazine, which resulted in 48.5% ± 1.2% (SD) atrazine degradation. The tactic described right here provides a number of benefits over present extraction and synthesis strategies, that are extra cumbersome, use hazardous chemical compounds, and yield solely small portions of purified compound. The newly developed methodology will facilitate future analysis characterizing the chemical conduct of DIBOA-Glc and decide its potential as an atrazine mitigation and remediation software.

Human recombinant area antibodies in opposition to a number of sclerosis antigenic peptide CSF114(Glc).

A number of sclerosis (MS) is a power auto-immune illness characterised by a injury to the myelin part of the central nervous system. Self-antigens created by aberrant glycosylation have been described to be a key part within the formation of auto-antibodies.  We reasoned that antibodies raised in opposition to this probe may have been related for MS.

Magnetic Beads DNA Extraction Kit (Food)

MF004 each
EUR 3

Magnetic Beads DNA Extraction Kit (Food)

MF048 each
EUR 55

Magnetic Beads DNA Extraction Kit (Food)

MF096 each
EUR 99

Magnetic Beads DNA Extraction Kit (Blood)

MB004 each
EUR 3

Magnetic Beads DNA Extraction Kit (Blood)

MB048 each
EUR 40

Magnetic Beads DNA Extraction Kit (Blood)

MB096 each
EUR 75

Magnetic Beads DNA Extraction Kit (Plant)

MP004 each
EUR 3

Magnetic Beads DNA Extraction Kit (Plant)

MP048 each
EUR 55

Magnetic Beads DNA Extraction Kit (Plant)

MP096 each
EUR 99

Magnetic Beads for DNA Purification

M1502-5 5 ml
EUR 332.4

Magnetic Beads DNA Extraction Kit (Bacteria)

ME004 each
EUR 3

Magnetic Beads DNA Extraction Kit (Bacteria)

ME048 each
EUR 60

Magnetic Beads DNA Extraction Kit (Bacteria)

ME096 each
EUR 110

Magnetic Beads for DNA size selection

AG0103 5 ml, 60 ml Ask for price
Description: The Magnetic Beads are ideal for DNA purification, concentration and size selection, along with next-generation sequencing library preparation kits.

Magnetic Beads

TRI-C86M05L 1000mL
EUR 8001

Magnetic Beads

TRI-C86M05M 200mL
EUR 1688.4

Magnetic Beads

TRI-C86M05S 100mL
EUR 844.2

Magnetic Beads-Based Plant Genomic DNA Kit

abx460019-1096tests 10 × 96 tests Ask for price

Magnetic Beads-Based Plant Genomic DNA Kit

abx460019-596tests 5 × 96 tests Ask for price

Magnetic Beads-Based Plant Genomic DNA Kit

abx460019-96tests 96 tests
EUR 437.5

Magnetic Beads-Based Blood Genomic DNA Kit

abx460020-1096tests 10 × 96 tests Ask for price

Magnetic Beads-Based Blood Genomic DNA Kit

abx460020-596tests 5 × 96 tests Ask for price

Magnetic Beads-Based Blood Genomic DNA Kit

abx460020-96tests 96 tests
EUR 437.5

FFPE Tissue DNA Extraction Kit - Magnetic Beads

K5011450 1 kit
EUR 261

Magnetic Beads-Based Tissue Genomic DNA Kit

abx460016-1096tests 10 × 96 tests Ask for price

Magnetic Beads-Based Tissue Genomic DNA Kit

abx460016-596tests 5 × 96 tests Ask for price

Magnetic Beads-Based Tissue Genomic DNA Kit

abx460016-96tests 96 tests
EUR 437.5

Magnetic Beads Soil Genomic DNA Extraction Kit

MS004 each
EUR 3.5

Magnetic Beads Soil Genomic DNA Extraction Kit

MS048 each
EUR 65

Magnetic Beads Soil Genomic DNA Extraction Kit

MS096 each
EUR 120

Magnetic Beads-Based Bacteria Genomic DNA Kit

abx460017-1096tests 10 × 96 tests Ask for price

Magnetic Beads-Based Bacteria Genomic DNA Kit

abx460017-596tests 5 × 96 tests Ask for price

Magnetic Beads-Based Bacteria Genomic DNA Kit

abx460017-96tests 96 tests
EUR 437.5

Magnetic Beads (RNA)

AG0104 5 ml, 60 ml Ask for price
Description: The Magnetic Beads (RNA)</strong> are automated for highly efficient RNA purification by specific adsorption.

Magnetic Beads Viral DNA/RNA Extraction Kit II

MV004 each
EUR 3

Magnetic Beads Viral DNA/RNA Extraction Kit II

MV048 each
EUR 72

Magnetic Beads Viral DNA/RNA Extraction Kit II

MV096 each
EUR 128

Magnetic Beads Viral DNA/RNA Extraction Kit II

MV480 each
EUR 590

Magnetic Beads-Based Buffy Coat Genomic DNA Kit

abx460015-1096tests 10 × 96 tests Ask for price

Magnetic Beads-Based Buffy Coat Genomic DNA Kit

abx460015-596tests 5 × 96 tests Ask for price

Magnetic Beads-Based Buffy Coat Genomic DNA Kit

abx460015-96tests 96 tests
EUR 437.5

Streptavidin Magnetic Beads

HY-K0208 5 mL
EUR 645.6

Streptavidin Magnetic beads

EA-IP-011M 1mL
EUR 241
Description: Primary Antibodies

Anti-HA magnetic beads

B26201 1 mL
EUR 579.6
Description: Anti-HA magnetic beads kit is based on hydroxyl magnetic beads covalently coupling with high quality mouse IgG2b monoclonal antibody, used for co-immunoprecipitation and protein purification.

Anti-HA magnetic beads

B26202 5 mL
EUR 1742.4
Description: Anti-HA magnetic beads kit is based on hydroxyl magnetic beads covalently coupling with high quality mouse IgG2b monoclonal antibody, used for co-immunoprecipitation and protein purification.

Anti-HA Magnetic Beads

HY-K0201 1 mL
EUR 334.8

SILICA MAGNETIC BEADS 1L

L5011001 1 liter
EUR 7260

Protein A Magnetic Beads

6507-1 each
EUR 314.4

Protein G Magnetic Beads

6517-1 each
EUR 314.4

Protein L Magnetic Beads

6537-1 each
EUR 352.8

Anti-Myc magnetic beads

B26301 1 mL
EUR 579.6
Description: Anti-Myc magnetic beads kit is based on hydroxyl magnetic beads covalently coupling with mouse IgG1 monoclonal antibody.it is recommended to use for co-immunoprecipitation and protein purification.

Anti-Myc magnetic beads

B26302 5 mL
EUR 1742.4
Description: Anti-Myc magnetic beads kit is based on hydroxyl magnetic beads covalently coupling with mouse IgG1 monoclonal antibody.it is recommended to use for co-immunoprecipitation and protein purification.

Protein A Magnetic Beads

HY-K0203 1 mL
EUR 148.8

Protein G Magnetic Beads

HY-K0204 5 mL
EUR 445.2

Protein A Magnetic beads

EA-IP-015M 1mL
EUR 105
Description: Primary Antibodies

Protein G Magnetic beads

EA-IP-016M 1mL
EUR 105
Description: Primary Antibodies

Protein L Magnetic beads

EA-IP-017M 1mL
EUR 105
Description: Primary Antibodies

Anti-Flag magnetic beads

B26101 1 mL
EUR 579.6
Description: Anti-Flag magnetic beads is based on hydroxyl magnetic beads covalently coupling with mouse IgG1 monoclonal antibody. It is recommended to use for co-immunoprecipitation and protein purification.

Anti-Flag magnetic beads

B26102 5 mL
EUR 1742.4
Description: Anti-Flag magnetic beads is based on hydroxyl magnetic beads covalently coupling with mouse IgG1 monoclonal antibody. It is recommended to use for co-immunoprecipitation and protein purification.

Anti-Flag Magnetic Beads

HY-K0207 1 mL
EUR 570

SILICA MAGNETIC BEADS 10ML

L5011010 10 ml
EUR 73

BlackPearl® (Magnetic Beads)

20161006-1 - Ask for price

BlackPearl® (Magnetic Beads)

20161006-2 - Ask for price

BlackPearl® (Magnetic Beads)

20161006-3 - Ask for price

Concanavalin A Magnetic Beads

K1308-1 1ml
EUR 44.8
Description: Protein & Immunology|Protein Purification and isolation

Concanavalin A Magnetic Beads

K1308-5 5x1ml
EUR 196.8
Description: Protein & Immunology|Protein Purification and isolation

Magnetic Beads™ Streptavidin

SMB-B01 5mg
EUR 149.8
Description: The Streptavidin-Magnetic Beads are 2.8 µm superparamagnetic particles covalently coupled to a highly pure form of streptavidin (SA). The beads can be used to capture the biotinylated proteins or other molecules, because Streptavidin (SA) has an extraordinarily high affinity for biotin with a dissociation constant (Kd) on the order of 10−14 mol/L, the Biotinylated molecules can bind to the SA irreversibly.Streptavidin is a tetrameric protein purified from the bacterium Streptomyces avidin, and exhibits high binding affinity for biotin. Able to bind one molecule of biotin with each subunit. Streptavidin (PI=6.0-7.5) has lower level of non-specific binding to various biological components at physiological pH than avidin (PI=7.4), resulting from its isoelectric point (PI).The Streptavidin-Magnetic Beads is easy to capture the biotinylated proteins or other molecules in Chemiluminescence procedures, and the bounded protein have no activity lost, this ready to use products could greatly save your protein coupling time and hassle, and help us get the best performance and highly reproducible results.

Concanavalin A Magnetic beads

EA-IP-014M 1mL
EUR 159
Description: Primary Antibodies

IP/CoIP Kit (Magnetic Beads)

EA-IP-K007M 50T
EUR 700
Description: Antibody Application Reagents

Protein A/G Magnetic Beads

6527-1 each
EUR 352.8

Protein A/G Magnetic Beads

HY-K0202 1 mL
EUR 157.2

Protein A/G Magnetic Beads

EA-IP-007M 1mL
EUR 80
Description: Primary Antibodies

Anti-c-Myc Magnetic Beads

HY-K0206 5 mL
EUR 1368

Anti-tGFP magnetic beads, 1ml

TA150039 1 ml Ask for price

Anti-tGFP magnetic beads, 5ml

TA150040 5 ml Ask for price

9E10, Anti-Myc Magnetic beads

TA150044 1 ml Ask for price

9E10, Anti-Myc Magnetic beads

TA150045 5 ml Ask for price

Magnetic Beads PCR Cleanup Kit

MC004 each
EUR 3

Magnetic Beads PCR Cleanup Kit

MC048 each
EUR 25

Magnetic Beads PCR Cleanup Kit

MC096 each
EUR 45

Anti-HA (Nanobody) Magnetic Beads

AE109 500μL
EUR 403

Anti-GFP (Nanobody) Magnetic Beads

AE079 500μL
EUR 312

Anti-Myc (Nanobody) Magnetic Beads

AE107 1000μL
EUR 213.2

Human FAP-coupled Magnetic Beads

MBS-K077 10mg
EUR 882.9
Description: The biotinylated FAP protein was conjugated to streptavidin magnetic beads. This pre-coupled magnetic bead product can capture the anti-FAP antibody from various assay systems. The beads are in uniform size, narrow size distribution with large surface area and unique surface coating, which can help you get the best performance and highly reproducible results. This FAP coupled magnetic beads will bring great convenience with minimum non-specific binding and developed protocols. This ready-to-use product could greatly save your time and hassle.

Anti-GFP (Nanobody) Magnetic Beads

MBS9143967-INQUIRE INQUIRE Ask for price

Human CD19-coupled Magnetic Beads

MBS-K005-10mg 10mg
EUR 4392.7
Description: Human CD19 protein is expressed from human 293 cells (HEK293). It contains AA Pro 20 - Lys 291(Accession # P15391-1).

Human CD19-coupled Magnetic Beads

MBS-K005-2mg 2mg
EUR 1427.9
Description: Human CD19 protein is expressed from human 293 cells (HEK293). It contains AA Pro 20 - Lys 291(Accession # P15391-1).

Human CD33-coupled Magnetic Beads

MBC-K008 2mg
EUR 2707.1
Description: Human CD33 protein is expressed from human 293 cells (HEK293). It contains AA Asp 18 - His 259(Accession # P20138-1(R69G)).

Human CD38-coupled Magnetic Beads

MBC-K010 2mg
EUR 2707.1
Description: Human CD38 protein is expressed from human 293 cells (HEK293). It contains AA Val 43 - Ile 300(Accession # P28907-1).

Human EGFR-coupled Magnetic Beads

MBE-K012 2mg
EUR 2707.1
Description: Human EGFR protein is expressed from human 293 cells (HEK293). It contains AA Leu 25 - Ser 645(Accession # P00533-1).

Human PSMA-coupled Magnetic Beads

MBP-K007 2mg
EUR 3349.1
Description: Human PSMA protein is expressed from human 293 cells (HEK293). It contains AA Lys 44 - Ala 750(Accession # Q04609-1).

Human ROR1-coupled Magnetic Beads

MBR-K009 2mg
EUR 2707.1
Description: Human ROR1 protein is expressed from human 293 cells (HEK293). It contains AA Gln 30 - Glu 403(Accession # Q01973-1).

Human BCMA-coupled Magnetic Beads

MBS-K004 2mg
EUR 2707.1
Description: Human BCMA protein is expressed from human 293 cells (HEK293). It contains AA Met 1 - Ala 54(Accession # Q02223-1).

Human CD19-coupled Magnetic Beads

MBS-K005 2mg
EUR 4312.1
Description: Human CD19 protein is expressed from human 293 cells (HEK293). It contains AA Pro 20 - Lys 291(Accession # P15391-1).

Human HER2-coupled Magnetic Beads

MBS-K006 500ug
EUR 2835.5
Description: Human HER2 protein is expressed from human 293 cells (HEK293). It contains AA Thr 23 - Thr 652(Accession # P04626-1).

Human ACE2-coupled Magnetic Beads

MBS-K013 2mg
EUR 2707.1
Description: Human ACE2 protein is expressed from human 293 cells (HEK293). It contains AA Gln 18 - Ser 740(Accession # Q9BYF1-1).

Human CD73-coupled Magnetic Beads

MBS-K022 2mg
EUR 3349.1
Description: Human CD73 Protein is expressed from human 293 cells (HEK293). It contains AA Trp 27 - Ser 549(Accession # P21589-1).

Human CD47-coupled Magnetic Beads

MBS-K023 2mg
EUR 2707.1
Description: Human CD47 Protein is expressed from human 293 cells (HEK293). It contains AA Gln 19 - Pro 139(Accession # Q08722).

Human CD3E-coupled Magnetic Beads

MBS-K026 2mg
EUR 2707.1
Description: Human CD3E Protein is expressed from human 293 cells (HEK293). It contains AA Asp 23 - Asp 126(Accession # P07766-1).

Human CD22-coupled Magnetic Beads

MBS-K052 2mg
EUR 4312.1
Description: Human CD22 Protein is expressed from human 293 cells (HEK293). It contains AA Asp 20 - Arg 687(Accession # P20273-1).

Human DLL3-coupled Magnetic Beads

MBS-K053 2mg
EUR 2707.1
Description: Delta-like protein 3 (DLL3) is a transmembrane protein that belongs to the Delta/Serrate/Lag-2 (DSL) family of Notch ligands.May be required to divert neurons along a specific differentiation pathway. Plays a role in the formation of somite boundaries during segmentation of the paraxial mesoderm. DLL3 protein is expressed on the surface of tumor cells but not in normal adult tissues.

Human uPAR-coupled Magnetic Beads

MBS-K076 2mg
EUR 2707.1
Description: Tumors are the result of uncontrolled proliferation of cells in different organs. Tumor development is a multistage process, that includes the generation of primary tumors, separation of tumors from primary sites, degradation of extracellular matrix (ECM), and distant metastasis of tumors. A variety of genes play important roles in the development of tumors, including the cell surface receptor urokinase-type plasminogen activator receptor (uPAR). uPAR is highly expressed in a variety of tumor cells, and a variety of signals regulated by uPAR play significant roles in tumor cell proliferation and metastasis, tumor-related glycolysis, the tumor microenvironment and angiogenesis. Studies have found that some specific drugs and antibodies have unique inhibitory effects on uPAR.

DDDDK-Tag Antibody (Magnetic Beads)

abx005594-100l 100 µl
EUR 250

Protein A/G/L Magnetic Beads

6547-1 each
EUR 405.6

Amylose BlackPearl® (Magnetic Beads)

20161009-1 - Ask for price

Amylose BlackPearl® (Magnetic Beads)

20161009-2 - Ask for price

Human PCSK9-coupled Magnetic Beads

MBS-K054 2mg
EUR 2707.1
Description: Proprotein convertase subtilisin/kexin type 9 (PCSK9) is also known as NARC1 (neural apoptosis regulated convertase), is a newly identified subtilase belonging to the peptidase S8 subfamily. Mouse PCSK9 is synthesized as a soluble zymogen, and undergoes autocatalytic intramolecular processing in the endoplasmic reticulum, resulting in the cleavage of its propeptide that remains associated with the secreted active enzyme with a broad alkaline pH optimum. This protein plays a major regulatory role in cholesterol homeostasis. PCSK9 binds to the epidermal growth factor-like repeat A (EGF-A) domain of the low-density lipoprotein receptor (LDLR), inducing LDLR degradation. PCSK9 may also have a role in the differentiation of cortical neurons. Mutations in this gene have been associated with a rare form of autosomal dominant familial hypercholesterolemia (HCHOLA3).

Human ASGR1-coupled Magnetic Beads

MBS-K055 2mg
EUR 2707.1
Description: ASGPR, a transmembrane C-type lectin, recognizes a wide variety of ligands that contain either terminal galactose (Gal) or N-acetylgalactosamine (GalNAc) residues and has been identified as a highly selective receptor on hepatocytes. The ASGR is composed of both a major (ASGR1) and minor subunit (ASGR2). ASGR1 has been shown to be efficiently targeted to the plasma membrane and to undergo constitutive endocytosis and recycling and found mainly expressed in the human liver.

Human ANGPT2-coupled Magnetic Beads

MBS-K035 2mg
EUR 2707.1
Description: Human ANGPT2 Protein is expressed from human 293 cells (HEK293). It contains AA Lys 275 - Phe 496(Accession # O15123-1).

Human VEGF165-coupled Magnetic Beads

MBS-K036 2mg
EUR 2707.1
Description: Human VEGF165 Protein is expressed from human 293 cells (HEK293). It contains AA Ala 27 - Arg 191(Accession # P15692-4).

Human EGFRvIII-coupled Magnetic Beads

MBS-K020 2mg
EUR 2707.1
Description: Human EGFRvIII Protein is expressed from human 293 cells (HEK293). It contains AA Leu 25- Ser 378(Accession # NP_001333870.1).

Ni-NTA Magnetic Agarose Beads

20-512M1 2ml/Unit
EUR 116.39
Description: Suspension, 5% Magnetic Resin

Ni-NTA Magnetic Agarose Beads

20-512M2 5ml/Unit
EUR 263.6
Description: Suspension, 5% Magnetic Resin

Ni-NTA Magnetic Agarose Beads

20-512M3 10ml/Unit
EUR 477.13
Description: Suspension, 5% Magnetic Resin

Streptavidin BlackPearl® (Magnetic Beads)

20161004-1 - Ask for price

Streptavidin BlackPearl® (Magnetic Beads)

20161004-2 - Ask for price

Human Mesothelin-coupled Magnetic Beads

MBS-K024 2mg
EUR 2707.1
Description: Human Mesothelin Protein is expressed from human 293 cells (HEK293). It contains AA Glu 296 - Gly 580(Accession # Q13421-3(R309P)).

Human HGF R-coupled Magnetic Beads

MBS-K021 2mg
EUR 2707.1
Description: Human HGF R Protein is expressed from human 293 cells (HEK293). It contains AA Glu 25 - Thr 932(Accession # P08581).

Human CTLA-4 coupled Magnetic Beads

MBS-K042 2mg
EUR 2707.1
Description: Human CTLA-4 Protein is expressed from human 293 cells (HEK293). It contains AA Ala 37 - Phe 162(Accession # Q6GR94-1).

Protein A BlackPearl® (Magnetic Beads)

20161000-1 - Ask for price

Protein A BlackPearl® (Magnetic Beads)

20161000-2 - Ask for price

Protein A BlackPearl® (Magnetic Beads)

20161000-3 - Ask for price

Protein G BlackPearl® (Magnetic Beads)

20161003-1 - Ask for price

Protein G BlackPearl® (Magnetic Beads)

20161003-2 - Ask for price

Nickel (Ni2+) BlackPearl® (Magnetic Beads)

20161010-1 - Ask for price

Nickel (Ni2+) BlackPearl® (Magnetic Beads)

20161010-2 - Ask for price

Human TROP-2-coupled Magnetic Beads

MBS-K028 2mg
EUR 2707.1
Description: Human TROP-2 Protein is expressed from human 293 cells (HEK293). It contains AA Gln 31 - Thr 274(Accession # P09758-1).

Protein A/G Magnetic Beads for IP

B23201 1 ml
EUR 158.4
Description: Protein A/G Magnetic Beads for immunoprecipitation (IP) are based on a biological nanosurface technology (S-TEC). Protein A/G coats the surface of super paramagnetic microspheres with high coating density up to 9.3 × 10^13 molecules/cm2. Compared to similar immune magnetic beads, our Protein A/G beads display much more antibody binding sites therefore using less magnetic beads per reaction and ultimately achiving greater cost-efficiency. Non-specific binding is reduced to an absolute low eliminating any detectable interference with your IP assays. The large, specific surface area of the beads greatly shortens the adsorption time and achieves complete antibody/antigen adsorption process in 10 minutes and complete total purification and precipitation in just 30 minutes. This product can be used on a wide variety of samples, such as in cell lysates, supernatants collected from cell secretion, serum, ascites, and other immune antigens.

Protein A/G Magnetic Beads for IP

B23202 5 ml
EUR 558
Description: Protein A/G Magnetic Beads for immunoprecipitation (IP) are based on a biological nanosurface technology (S-TEC). Protein A/G coats the surface of super paramagnetic microspheres with high coating density up to 9.3 × 10^13 molecules/cm2. Compared to similar immune magnetic beads, our Protein A/G beads display much more antibody binding sites therefore using less magnetic beads per reaction and ultimately achiving greater cost-efficiency. Non-specific binding is reduced to an absolute low eliminating any detectable interference with your IP assays. The large, specific surface area of the beads greatly shortens the adsorption time and achieves complete antibody/antigen adsorption process in 10 minutes and complete total purification and precipitation in just 30 minutes. This product can be used on a wide variety of samples, such as in cell lysates, supernatants collected from cell secretion, serum, ascites, and other immune antigens.

Magnetic Beads Micro gDNA Extraction Kit

MM004 each
EUR 3

Magnetic Beads Micro gDNA Extraction Kit

MM048 each
EUR 63

Magnetic Beads Micro gDNA Extraction Kit

MM096 each
EUR 113

Anti-mCherry (Nanobody) Magnetic Beads Ab

AE094 1000μL
EUR 213.2

Human Nectin-4-coupled Magnetic Beads

MBS-K039 2mg
EUR 2707.1
Description: Human Nectin-4 Protein is expressed from human 293 cells (HEK293). It contains AA Gly 32 - Ser 349(Accession # Q96NY8-1).

Calmodulin (CAM) BlackPearl® (Magnetic Beads)

20161002-1 - Ask for price

Calmodulin (CAM) BlackPearl® (Magnetic Beads)

20161002-2 - Ask for price

Calmodulin (CAM) BlackPearl® (Magnetic Beads)

20161002-3 - Ask for price

Glutathione (GSH) BlackPearl® (Magnetic Beads)

20161007-1 - Ask for price

Glutathione (GSH) BlackPearl® (Magnetic Beads)

20161007-2 - Ask for price

Glutathione (GSH) BlackPearl® (Magnetic Beads)

20161007-3 - Ask for price

Human B7-H3(4Ig)-coupled Magnetic Beads

MBS-K040 2mg
EUR 2707.1
Description: Human B7-H3 Protein is expressed from human 293 cells (HEK293). It contains AA Gly 27 - Thr 461(Accession # Q5ZPR3-1).

Mouse monoclonal eRFP antibody, Magnetic beads

TA183034 1 ml Ask for price

Mouse monoclonal eCFP antibody, Magnetic beads

TA183036 1 ml Ask for price

Mouse monoclonal mRFP antibody, Magnetic beads

TA183041 1 ml Ask for price

Mouse monoclonal mRFP antibody, Magnetic beads

TA183042 1 ml Ask for price

Mouse monoclonal mRFP antibody, Magnetic beads

TA183043 1 ml Ask for price

Mouse monoclonal mPlum antibody, Magnetic beads

TA183037 1 ml Ask for price

Mouse monoclonal DsRed2 antibody, Magnetic beads

TA183025 1 ml Ask for price

Mouse monoclonal AsRed2 antibody, Magnetic beads

TA183045 1 ml Ask for price

Clone OTI4C5, Anti-DDK (FLAG) Magnetic beads

TA150036 5 ml Ask for price

Clone OTI4C5, Anti-DDK (FLAG) Magnetic beads

TA150042 1 ml Ask for price

Universal IP/Co-IP Toolkit (Magnetic Beads)

KTD104-EN-each each Ask for price

Universal IP/Co-IP Toolkit (Magnetic Beads)

KTD104-EN-Null Null Ask for price

Universal IP/Co-IP Toolkit (Magnetic Beads)

KTD104-EN-20T 20 T
EUR 169
Description: Antibody coupling magnetic beads, suitable for IP/ CO-IP experiment, protein purification.

Mouse monoclonal mCherry antibody, Magnetic beads

TA183030 1 ml Ask for price

Mouse monoclonal mBanana antibody, Magnetic beads

TA183032 1 ml Ask for price

Mouse monoclonal Dendra2 antibody, Magnetic beads

TA183044 1 ml Ask for price

Mouse monoclonal tdTomato antibody, Magnetic beads

TA183027 1 ml Ask for price

Mouse monoclonal ZsYellow1 antibody, Magnetic beads

TA183024 1 ml Ask for price

Mouse monoclonal mStrawberry antibody, Magnetic beads

TA183033 1 ml Ask for price

Universal IP/Co-IP Tool kit (Magnetic Beads)

MBS9719229-20Tests 20Tests
EUR 240

Universal IP/Co-IP Tool kit (Magnetic Beads)

MBS9719229-5x20Tests 5x20Tests
EUR 1050

PE-labeled Human CD47-coupled Magnetic Beads

MBS-K059 2.5mg
EUR 4536.8
Description: Leukocyte surface antigen CD47 is also known as Antigenic surface determinant protein OA3, Integrin-associated protein (IAP) and Protein MER6. CD47 contains 1 Ig-like V-type (immunoglobulin-like) domain. CD47 is very broadly distributed on normal adult tissues. CD47 has a role in both cell adhesion by acting as an adhesion receptor for THBS1 on platelets, and in the modulation of integrins and plays an important role in memory formation and synaptic plasticity in the hippocampus by similarity. CD47 is the receptor for SIRPA, binding to which prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells. CD47 Interaction with SIRPG mediates cell-cell adhesion, enhances superantigen-dependent T-cell-mediated proliferation and costimulates T-cell activation.

VAHTS Concanavalin A-coated Magnetic Beads Pro

N515-01-250ul 250 μl
EUR 38.7

VAHTS Concanavalin A-coated Magnetic Beads Pro

N515-02-1ml 1 ml
EUR 129.71

VAHTS Concanavalin A-coated Magnetic Beads Pro

N515-03-5ml 5 ml
EUR 610.95

We subsequently screened a human Area Antibody library in opposition to CSF114(Glc) utilizing magnetic separation as a panning methodology. We obtained and described a number of clones, and the one with the very best indicators was produced as a 6×His-tagged protein to correctly examine the binding properties as a soluble antibody.

Leave a Reply

Your email address will not be published. Required fields are marked *