The glycan role in the glycopeptide immunogenicity revealed by atomistic simulations and spectroscopic experiments on the multiple sclerosis biomarker CSF114(Glc).

The glycan role in the glycopeptide immunogenicity revealed by atomistic simulations and spectroscopic experiments on the multiple sclerosis biomarker CSF114(Glc).

Glycoproteins are sometimes acknowledged as not-self molecules by antibodies triggering the onset of extreme autoimmune illnesses resembling A number of Sclerosis (MS). Thus, the event of antigen-mimicking biomarkers represents a sexy technique for an early analysis of the illness. An instance is the artificial glycopeptide CSF114(Glc), which was designed and examined as MS biomarker and whose scientific utility was restricted by its diminished capability to detect autoantibodies in MS sufferers. Within the try to enhance the efficacy of CSF114(Glc), we’ve characterised all of the occasions resulting in the ultimate binding of the biomarker to the autoantibody utilizing atomistic simulations, ESR and NMR experiments. The glycosydic moiety performs a major function in the entire course of.

Particularly, in an setting mimicking that used within the scientific checks the glycopeptide assumes a α-helix construction that’s useful for the interplay with the antibody. On this conformation CSF114(Glc) binds the monoclonal antibody mAb8-18C5 equally to the myelin oligodendrocyte glycoprotein MOG, which is a identified MS auto-antigen, thus explaining its diagnostic exercise. Our examine provides new molecular bases to design more practical biomarkers and offers a most legitimate protocol to analyze different methods the place the setting impact is determinant for the organic exercise.

The current examine was carried out to look at the dissipation sample of triazophos on capsicum and danger evaluation of its residues on human beings and to recommend a ready interval for the protection of customers. Following two functions of triazophos (Truzo 40 EC) at 500 and 1000 g a.i. ha(-1), the typical preliminary deposits had been discovered to be 3.61 and 6.26 mg kg(-1), respectively. These residues dissipated beneath the restrict of quantification (LOQ) of 0.05 mg kg(-1) in 10 and 15 days on the beneficial and double the beneficial dosages, respectively. The calculated values of half-life had been 2.31 and a couple of.

14 days at beneficial and double the beneficial dosages, respectively. Theoretical most residue contribution (TMRC) values had been discovered to be 28.eight and 41.6 μg individual(-1) day(-1) at 500 and 1000 g a.i. ha(-1), respectively, and located to be beneath the utmost permissible consumption on capsicum fruit on the seventh day. Subsequently, a ready interval of seven days is recommended for consumption of capsicum sprayed with triazophos on the beneficial dosages.

Preliminary examine on utility of urine amino acids profiling for monitoring of renal tubular damage utilizing GLC-MS.

The early analysis of the nephrotoxic impact of xenobiotics and medicines remains to be an unsolved drawback. Current research recommend a correlation between the nephrotoxic exercise of xenobiotics and elevated focus of amino acids in urine. The introduced examine was targeted on the applying of GLC-MS methodology for amino acids profiling in human urine as a noninvasive methodology for monitoring of kidney situation and tubular damage degree.
The analytic methodology relies on the conversion of the amino acids current within the pattern to tert-butyldimethylsilyl (TBDMS) derivatives and their evaluation by gas-liquid chromatography-mass spectrometry (GLC-MS). The process of urine pattern preparation for chromatographic evaluation was optimized. CSF114(Glc) is an artificial glucopeptide detecting in vitro MS-specific auto-antibodies, and it’s actively utilized in diagnostics and analysis to observe and quantify MS-associated Ig ranges.
The presence of 12 amino acids in a lot of the examined wholesome human urine samples was detected. The numerous variations within the ranges of specific amino acids between sufferers with tubular damage and wholesome controls had been discovered, particularly for lysine, valine, serine, alanine and leucine. We discovered that this strategy based mostly on GLC-MS detection can be utilized in nephrotoxicity research for urine amino acids monitoring in publicity to xenobiotics and medicines.
The glycan role in the glycopeptide immunogenicity revealed by atomistic simulations and spectroscopic experiments on the multiple sclerosis biomarker CSF114(Glc).

A easy methodology for isolation and purification of DIBOA-Glc from Tripsacum dactyloides.

Naturally occurring benzoxazinones (Bx) are a extremely reactive class of compounds which have obtained specific consideration prior to now a number of many years. Lately, we recognized 2-β-D-glucopyranosyloxy-4-hydroxy-1,4-benzoxazin-3-one (DIBOA-Glc) because the compound current within the roots of Japanese gamagrass {Tripsacum dactyloides (L.)} accountable for atrazine degradation. Nonetheless, characterization of the DIBOA-Glc/atrazine degradation response has been restricted on account of difficulties achieve ample portions of purified DIBOA-Glc.

The target of the examine was to develop a easy purification and isolation methodology for acquiring bulk portions of extremely purified DIBOA-Glc. T. dactyloides roots had been extracted with 90% aqueous methanol, and the crude extract was fractionated utilizing an HPLC geared up with a C8 semi-prep column and fraction collector. UHPLC-DAD-MS/MS was used to verify the identification of DIBOA-Glc within the fractions collected. Evaluation by 13C and 1H NMR and DAD indicated that 542 mg of DIBOA-Glc with a purity of>> 99% was obtained.

The reactivity of the DIBOA-Glc was confirmed in a 16 hour assay with atrazine, which resulted in 48.5% ± 1.2% (SD) atrazine degradation. The tactic described right here provides a number of benefits over present extraction and synthesis strategies, that are extra cumbersome, use hazardous chemical compounds, and yield solely small portions of purified compound. The newly developed methodology will facilitate future analysis characterizing the chemical conduct of DIBOA-Glc and decide its potential as an atrazine mitigation and remediation software.

Human recombinant area antibodies in opposition to a number of sclerosis antigenic peptide CSF114(Glc).

A number of sclerosis (MS) is a power auto-immune illness characterised by a injury to the myelin part of the central nervous system. Self-antigens created by aberrant glycosylation have been described to be a key part within the formation of auto-antibodies.  We reasoned that antibodies raised in opposition to this probe may have been related for MS.

Anti-Myc magnetic beads

B26301 1 mL
EUR 579.6
Description: Anti-Myc magnetic beads kit is based on hydroxyl magnetic beads covalently coupling with mouse IgG1 monoclonal antibody.it is recommended to use for co-immunoprecipitation and protein purification.

Anti-Myc magnetic beads

B26302 5 mL
EUR 1742.4
Description: Anti-Myc magnetic beads kit is based on hydroxyl magnetic beads covalently coupling with mouse IgG1 monoclonal antibody.it is recommended to use for co-immunoprecipitation and protein purification.

Anti-HA Magnetic Beads

HY-K0201 1 mL
EUR 334.8

Protein A Magnetic Beads

HY-K0203 1 mL
EUR 148.8

Protein G Magnetic Beads

HY-K0204 5 mL
EUR 445.2

Anti-Flag Magnetic Beads

HY-K0207 1 mL
EUR 570

Protein A Magnetic Beads

6507-1 each
EUR 314.4

Protein G Magnetic Beads

6517-1 each
EUR 314.4

Protein L Magnetic Beads

6537-1 each
EUR 352.8

Protein A/G Magnetic Beads

HY-K0202 1 mL
EUR 157.2

Anti-c-Myc Magnetic Beads

HY-K0206 5 mL
EUR 1368

Protein A/G Magnetic Beads

6527-1 each
EUR 352.8

Size Selection DNA Beads

20-abx298001
  • EUR 260.40
  • EUR 477.60
  • EUR 1663.20
  • 1 ml
  • 5 ml
  • 60 ml

VAHTS DNA Clean Beads

N411-01 5 ml
EUR 259.2

VAHTS DNA Clean Beads

N411-02 60 ml
EUR 634.8

VAHTS DNA Clean Beads

N411-03 450 ml
EUR 3055.2

Protein A/G/L Magnetic Beads

6547-1 each
EUR 405.6

Protein A/G Magnetic Beads for IP

B23201 1 ml
EUR 158.4
Description: Protein A/G Magnetic Beads for immunoprecipitation (IP) are based on a biological nanosurface technology (S-TEC). Protein A/G coats the surface of super paramagnetic microspheres with high coating density up to 9.3 × 10^13 molecules/cm2. Compared to similar immune magnetic beads, our Protein A/G beads display much more antibody binding sites therefore using less magnetic beads per reaction and ultimately achiving greater cost-efficiency. Non-specific binding is reduced to an absolute low eliminating any detectable interference with your IP assays. The large, specific surface area of the beads greatly shortens the adsorption time and achieves complete antibody/antigen adsorption process in 10 minutes and complete total purification and precipitation in just 30 minutes. This product can be used on a wide variety of samples, such as in cell lysates, supernatants collected from cell secretion, serum, ascites, and other immune antigens.

Protein A/G Magnetic Beads for IP

B23202 5 ml
EUR 558
Description: Protein A/G Magnetic Beads for immunoprecipitation (IP) are based on a biological nanosurface technology (S-TEC). Protein A/G coats the surface of super paramagnetic microspheres with high coating density up to 9.3 × 10^13 molecules/cm2. Compared to similar immune magnetic beads, our Protein A/G beads display much more antibody binding sites therefore using less magnetic beads per reaction and ultimately achiving greater cost-efficiency. Non-specific binding is reduced to an absolute low eliminating any detectable interference with your IP assays. The large, specific surface area of the beads greatly shortens the adsorption time and achieves complete antibody/antigen adsorption process in 10 minutes and complete total purification and precipitation in just 30 minutes. This product can be used on a wide variety of samples, such as in cell lysates, supernatants collected from cell secretion, serum, ascites, and other immune antigens.

Protein A Beads (1-2mg/ml)

B0001-10 10ml
EUR 486

Protein A Beads (1-2mg/ml)

B0001-25 25ml
EUR 973.2

Protein A Beads (1-2mg/ml)

B0001-5 5ml
EUR 291.6

Protein G Beads (1-2mg/ml)

B0002-10 10ml
EUR 729.6

Protein G Beads (1-2mg/ml)

B0002-25 25ml
EUR 1472.4

Protein G Beads (1-2mg/ml)

B0002-5 5ml
EUR 426

100 BP DNA LADDER, 500UL PER KIT

M-DNA-100BP 1/pk
EUR 87.6
Description: Bioscience Mol Bio; DNA Ladder

1 KB DNA LADDER, 500UL PER KIT

M-DNA-1KB 1/pk
EUR 84
Description: Bioscience Mol Bio; DNA Ladder

Bottle Centrifuge Pp 450 Ml

3141-0500 PK4
EUR 152.76

Magnetic Beads-conjugated Mouse anti DDDDK-Tag mAb

AE037 50 ul
EUR 211.2

Beads-for-Seeds (24 glass beads, each in a 1.5 ml tube)

M-CO-501 24 glass beads
EUR 71
Description: Beads-for-Seeds (24 glass beads, each in a 1.5 ml tube)

FAB & Beads(Ballotini Beads)

MED1042 PK50
EUR 91.2

Goat Anti-Rabbit IgG Beads (1-1.5mg/ml)

B0003-10 10ml
EUR 681.6

Goat Anti-Rabbit IgG Beads (1-1.5mg/ml)

B0003-25 25ml
EUR 1228.8

Goat Anti-Rabbit IgG Beads (1-1.5mg/ml)

B0003-5 5ml
EUR 426

Goat Anti-Mouse IgG Beads (1-1.5mg/ml)

B0004-10 10ml
EUR 644.4

Goat Anti-Mouse IgG Beads (1-1.5mg/ml)

B0004-25 25ml
EUR 1228.8

Goat Anti-Mouse IgG Beads (1-1.5mg/ml)

B0004-5 5ml
EUR 400.8

Rabbit Anti-Human IgG Beads (1-1.5mg/ml)

B0005-10 10ml
EUR 949.2

Rabbit Anti-Human IgG Beads (1-1.5mg/ml)

B0005-25 25ml
EUR 2008.8

Rabbit Anti-Human IgG Beads (1-1.5mg/ml)

B0005-5 5ml
EUR 547.2

Rabbit Anti-Rat IgG Beads (1-1.5mg/ml)

B0006-10 10ml
EUR 949.2

Rabbit Anti-Rat IgG Beads (1-1.5mg/ml)

B0006-25 25ml
EUR 2008.8

Rabbit Anti-Rat IgG Beads (1-1.5mg/ml)

B0006-5 5ml
EUR 547.2

Mouse Anti-Rabbit IgG Beads (1-1.5mg/ml)

B0007-10 10ml
EUR 644.4

Mouse Anti-Rabbit IgG Beads (1-1.5mg/ml)

B0007-25 25ml
EUR 1228.8

Mouse Anti-Rabbit IgG Beads (1-1.5mg/ml)

B0007-5 5ml
EUR 400.8

Mouse Anti-Human IgG Beads (1-1.5mg/ml)

B0008-10 10ml
EUR 949.2

Mouse Anti-Human IgG Beads (1-1.5mg/ml)

B0008-25 25ml
EUR 2008.8

Mouse Anti-Human IgG Beads (1-1.5mg/ml)

B0008-5 5ml
EUR 547.2

Circulating DNA Kit (with Magnetic Stand)

abx098869-50rxns 50 rxns
EUR 510

Circulating DNA Kit (with Magnetic Stand)

abx298026-50rxns 50 rxns
EUR 510

RNA/DNA Purification Kit (Magnetic Bead)

DA0623 32 test/kit Ask for price

Cyanine7 tetrazine, 25 mg

450 25 mg
EUR 615.6

Blood Genomic DNA Kit (with Magnetic Stand)

abx098867-50rxns 50 rxns
EUR 360

Viral DNA / RNA Kit (with Magnetic Stand)

abx098871-50rxns 50 rxns
EUR 477.6

Viral DNA/RNA Kit (with Magnetic Stand)

abx298029-50rxns 50 rxns
EUR 477.6

Latex Beads

abx291003-1L 1 L
EUR 2798.4

RNA Beads

20-abx298002
  • EUR 260.40
  • EUR 477.60
  • EUR 1663.20
  • 1 ml
  • 5 ml
  • 60 ml

Bulk Beads

D1131-01 1 PC
EUR 285.76

Bulk Beads

D1131-05 1 PC
EUR 285.76

Bulk Beads

D1131-10 1 PC
EUR 492.47

Bulk Beads

D1132-01TP 1 PC
EUR 492.47

Bulk Beads

D1132-05TP 1 PC
EUR 492.47

Bulk Beads

D1132-10TP 1 PC
EUR 492.47

Bulk Beads

D1132-15TP 1 PC
EUR 492.47

Bulk Beads

D1132-30TP 1 PC
EUR 492.47

Bulk Beads

D1132-60 1 PC
EUR 289.93

Bulk Beads

D1133-28 1 PC
EUR 112.45

Exorose Beads

EXOB-100 100 ml
EUR 127.2

Exorose Beads

EXOB-25 25 ml
EUR 69.6

Exorose Beads

EXOB-250 250 ml
EUR 225.6

Saline & Beads

MED1064 PK50
EUR 91.2

T4 DNA Polymerase (5,000 U/ml)

RK20539 25 U Ask for price

Refill Glass Beads

B1201-BEAD 1 PC
EUR 141.34

V5 agarose beads

AE029-100ul 100 ul Ask for price

V5 agarose beads

AE029-200ul 200 ul
EUR 273.6

V5 agarose beads

AE029-20ul 20 ul Ask for price

V5 agarose beads

AE029-50ul 50 ul Ask for price

Glass Beads 0.1mm

GB01 1pack
EUR 129.6
Description: Glass beads. 0.1mm. 1 lb. Non-sterile.

Glass Beads 0.5mm

GB05 1pack
EUR 123.6
Description: Glass beads. 0.5mm. 1 lb. Non-sterile.

Glass Beads 1.0mm

GB10 1pack
EUR 123.6
Description: Glass beads. 1.0mm. 1 lb. Non-sterile.

Sodium hydroxide, Beads

SB6789 500g
EUR 73.21

RanBP1 Agarose Beads

STA-421 400 µg
EUR 686.4
Description: RanBP1 Agarose Beads selectively pull down the active form of Ran. Beads are colored to allow for a visual check. These are the same beads supplied with our Small GTPase Activation Assays. 400 µg.

Protect beads green

SWA1151 PK80
EUR 103.74

Protect Beads White

SWA1155 PK80
EUR 103.74

Protect Beads Blue

SWA1158 PK80
EUR 103.74

Thrombin Sepharose Beads

7925-1 each
EUR 261.6

Thrombin Sepharose Beads

7925-25 each
EUR 2114.4

Thrombin Sepharose Beads

7925-5 each
EUR 836.4

Plasmin Sepharose Beads

7926-1 each
EUR 261.6

Plasmin Sepharose Beads

7926-25 each
EUR 2114.4

Plasmin Sepharose Beads

7926-5 each
EUR 836.4

Urokinase Sepharose Beads

7927-1 each
EUR 261.6

Urokinase Sepharose Beads

7927-25 each
EUR 2114.4

Urokinase Sepharose Beads

7927-5 each
EUR 836.4

Immobilized Catalase Beads

7931-1 each
EUR 183.6

Immobilized Catalase Beads

7931-10 each
EUR 705.6

Calmodulin-Sepharose Beads

7934-1 each
EUR 183.6

Calmodulin-Sepharose Beads

7934-10 each
EUR 574.8

Calmodulin-Sepharose Beads

7934-5 each
EUR 405.6

Streptavidin-Sepharose Beads

6565-10 each
EUR 836.4

Streptavidin-Sepharose Beads

6565-100 each Ask for price

Streptavidin-Sepharose Beads

6565-2 each
EUR 274.8

Streptavidin-Sepharose Beads

6565-5 each
EUR 483.6

EZEnrich? Polyubiquitin Beads

6568-300 each
EUR 444

Blood Genomic DNA Kit (0.1-20 ml)

abx098074-For200mlBlood For 200 ml Blood
EUR 427.2

Blood Genomic DNA Kit (0.1-20 ml)

abx098074-For50mlBlood For 50 ml Blood
EUR 260.4

illustra Ready-To-Go RT-PCR Beads 0.5 ml tubes 100 rxns

27926601 EACH
EUR 414.96

illustra Ready-To-Go RT-PCR Beads 0.2 ml tubes 96 rxns

27926701 EACH
EUR 386.46

illustra PuReTaq Ready-To-Go PCR Beads 0.5 ml tubes 100 rxns

27955801 EACH
EUR 159.6

Cot I human DNA conc. >=1,1 mg / ml

3001 500 µg
EUR 140.4

VAHTS mRNA Capture Beads

N401-01 24 rxn
EUR 171.6

VAHTS mRNA Capture Beads

N401-02 96 rxn
EUR 306

VAHTS RNA Clean Beads

N412-01 5 ml
EUR 286.8

VAHTS RNA Clean Beads

N412-02 40 ml
EUR 495.6

VAHTS RNA Clean Beads

N412-03 450 ml
EUR 4860

Stainless Steel Beads 0.2mm

SSB02 1pack
EUR 229.2
Description: Stainless steel beads. 0.2mm. 1 lb. Non-sterile.

Stainless Steel Beads 0.5mm

SSB05 1pack
EUR 229.2
Description: Stainless steel beads. 0.5mm. 1 lb. Non-sterile.

Stainless Steel Beads 1.6mm

SSB16 1pack
EUR 304.8
Description: Stainless steel beads. 1.6mm. 1 lb. Non-sterile.

Stainless Steel Beads 2.3mm

SSB23 1pack
EUR 260.4
Description: Stainless steel beads. 2.3mm. 1 lb. Non-sterile.

Stainless Steel Beads 3.2mm

SSB32 1pack
EUR 220.8
Description: Stainless steel beads. 3.2mm. 1 lb. Non-sterile.

Stainless Steel Beads 4.8mm

SSB48 1pack
EUR 220.8
Description: Stainless steel beads. 4.8mm. 1 lb. Non-sterile.

Stainless Steel Beads 6.0mm

SSB60 1pack
EUR 223.2
Description: Stainless steel beads. 6.0mm. 1 lb. Non-sterile.

PAK1 PBD Agarose Beads

STA-411 400 ?g
EUR 686.4
Description: PAK1 PBD Agarose Beads selectively pull down the active form of Rac and Cdc42. Beads are colored to allow for a visual check. These are the same beads supplied with our Small GTPase Activation Assays. 400 µg.

Rhotekin RBD Agarose Beads

STA-412 400 ?g
EUR 686.4
Description: Rhotekin RBD Agarose Beads selectively pull down the active form of Rho. Beads are colored to allow for a visual check. These are the same beads supplied with our Small GTPase Activation Assays. 400 µg.

RalGDS RBD Agarose Beads

STA-418 400 µg
EUR 686.4
Description: RalGDS RBD Agarose Beads selectively pull down the active form of Rap. Beads are colored to allow for a visual check. These are the same beads supplied with our Small GTPase Activation Assays. 400 µg.

GGA3 PBD Agarose Beads

STA-419 400 µg
EUR 686.4
Description: GGA3 PBD Agarose Beads selectively pull down the active form of Arf. Beads are colored to allow for a visual check. These are the same beads supplied with our Small GTPase Activation Assays. 400 µg.

RalBP1 PBD Agarose Beads

STA-420 400 µg
EUR 686.4
Description: RalBP1 RBD Agarose Beads selectively pull down the active form of Ral. Beads are colored to allow for a visual check. These are the same beads supplied with our Small GTPase Activation Assays. 400 µg.

Zirconium Oxide Beads 0.15mm

ZrOB015 1pack
EUR 189.6
Description: Fused Zirconium Oxide beads . 0.15mm. 1 lb. Non-sterile.

Zirconium Oxide Beads 0.5mm

ZrOB05 1pack
EUR 189.6
Description: Zirconium Oxide beads . 0.5mm. 1 lb. Non-sterile.

Zirconium Oxide Beads 1.0mm

ZrOB10 1pack
EUR 189.6
Description: Zirconium Oxide beads . 1.0mm. 1 lb. Non-sterile.

Zirconium Oxide Beads 2.0mm

ZrOB20 1pack
EUR 189.6
Description: Zirconium Oxide beads . 2.0mm. 1 lb. Non-sterile.

Zirconium Oxide Beads 2.5mm

ZrOB25 1pack
EUR 189.6
Description: Zirconium Oxide beads . 2.5mm. 1 lb. Non-sterile.

Zirconium Silicate Beads 0.5mm

ZSB05 1pack
EUR 146.4
Description: Zirconium Silicate beads . 0.5mm. 1 lb. Non-sterile.

Zirconium Silicate Beads 1.0mm

ZSB10 1pack
EUR 146.4
Description: Zirconium Silicate beads . 1.0mm. 1 lb. Non-sterile.

Rtg Rapd Analysis Beads

27950001 EACH
EUR 804.84

Glass Calibration Beads 4mm

SV144 500G
EUR 14.71

Protect Beads Mixed Colours

SWA1147 PK80
EUR 103.74

Calibration Beads for MoFlo

B28479 each
EUR 346.8
Description: Please reffer to the technical data sheet for more detail information for this item. Our dedicated team would be happy to assist you via live chat, email or phone.

Magnetic Stirrer

abx725038-1Unit 1 Unit
EUR 518.4

Magnetic Stand

abx799001-1Unit 1 Unit
EUR 309.6

Magnetic Separator

B23803 2 mL/200 uL/15 mL
EUR 291.6
Description: This Magnetic Separator is a proprietary machine, supportinga the magnetic beads series of products. A core tenent is the use of a superior magnetic, to ensure that magnetic separation step can be completed in a short time.

Magnetic Separator

MagSep1-1 1/pk
EUR 132

Magnetic Stirrer

H3760-SE 1 PC
EUR 121.85

Magnetic Stirrer

H4000-S-E 1 PC
EUR 97.22

Magnetic Stand

HY-K0200 200 μL-2 mL-15 mL
EUR 456

RNase-Free Calf Thymus DNA, 1 mg/mL (5x1mL)

9-31065
  • EUR 206.40
  • EUR 566.40
  • 1tube
  • 5tubes
Description: Minimum order quantity: 1 unit of 5tubes

cfPure® Cell Free DNA Extraction Kit, 100 ml

K5011610 1 kit
EUR 537.6

cfPure® Cell Free DNA Extraction Kit, 250 ml

K5011625 1 kit
EUR 897.6

Her2 / ErbB2 Recombinant Protein

11-450 0.1 mg
EUR 651.3
Description: Human Epidermal growth factor Receptor 2 (HER2) is also called ERBB2, HER-2,HER-2 /neu, NEU, NGL,TKR1 and c-erb B2,and is a protein giving higher aggressiveness in breast cancers. It is a member of the ErbB protein family, more commonly known as the epidermal growth factor receptor family. HER2 is a cell membrane surface-bound receptor tyrosine kinase and is normally involved in the signal transduction pathways leading to cell growth and differentiation. HER2 is thought to be an orphan receptor, with none of the EGF family of ligands able to activate it. Approximately 30% of breast cancers have an amplification of the HER2 gene or overexpression of its protein product. Overexpression of this receptor in breast cancer is associated with increased disease recurrence and worse prognosis. HER2 appears to play roles in development, cancer, communication at the neuromuscular junction and regulation of cell growth and differentiation .

CSF3 Recombinant Protein

90-450 10 ug
EUR 437.1
Description: G-CSF is a pleiotropic cytokine best known for its specific effects on the proliferation, differentiation and activation of hematopoietic cells of the neutrophilic granulocyte lineage. It is produced mainly by monocytes and macrophages upon activation by endotoxin, TNF-alpha and IFN-gamma. Other cell types including fibroblasts, endothelial cells, astrocytes and bone marrow stromal cells can also secrete G-CSF after LPS, IL-1 or TNF-alpha activation. In addition, various carcinoma cell lines and myeloblastic leukemia cells can express G-CSF constitutively. G-CSF stimulates growth, differentiation and functions of cells from the neutrophil lineage in vitro. Consistent with its in vitro functions, G-CSF has been found to play important roles in defense against infection, in inflammation and repair and in the maintenance of steady state hematopoiesis. Recombinant human G-CSF has been approved for the amelioration of chemotherapy induced neutropenia as well as for severe chronic neutropenia following marrow transplant.

VEGF-D Recombinant Protein

91-450 0.05 mg
EUR 651.3
Description: Vascular endothelial growth factor D (VEGF-D) is a member of the platelet-derived growth factor/vascular endothelial growth factor (PDGF/VEGF) family. It is highly expressed in lung, heart, small intestine and fetal lung, and at lower levels in skeletal muscle, colon, and pancreas. VEGF-D is growth factor active in angiogenesis, lymphangiogenesis and endothelial cell growth, stimulating their proliferation and migration and also has effects on the permeability of blood vessels. It may function in the formation of the venous and lymphatic vascular systems during embryogenesis, and also in the maintenance of differentiated lymphatic endothelium in adults. It undergoes a complex proteolytic maturation, generating multiple processed forms that bind and activate VEGFR-2 and VEGFR-3 receptors.

HLADG Recombinant Protein

92-450 0.05 mg
EUR 588.3
Description: Mouse HLA class II histocompatibility antigen gamma chain (CD74), is a single-pass type II membrane protein that in humans is encoded by the CD74 gene. It contains 1 thyroglobulin type-1 domain. CD74 Plays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha/beta heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic reticulum to compartments where peptide loading of class II takes place.

Filter for Accuris Microplate Reader

MR9600-450 1 PC
EUR 241.56

GFP-Rac1 Expression Vector Set

STA-450 1 kit
EUR 1939.2
Description: GFP-Rac1 Expression Vector Set contains 3 vectors: Rac wild type, T17N dominant negative mutant, and Q61L constitutively active mutant. Each vector also contains a GFP reporter sequence.

Recombinant (CHO cells) Hepatitis B Surface Antigen adr subtype (HBsAg)

RP-450 20 ug
EUR 196.8

Benzo(j)fluoranthene

S-450 1ML
EUR 70.68

Paritaprevir(ABT-450)

20-abx184297
  • EUR 1496.40
  • EUR 1095.60
  • 10 mg
  • 5 mg

Glass Beads 0.1mm RNase Free

GB01-RNA 1pack
EUR 115.2
Description: Glass beads. 0.1mm. 4mL. RNase free.

Glass Beads 0.5mm RNase Free

GB05-RNA 1pack
EUR 115.2
Description: Glass beads. 0.5mm. 4mL. RNase free.

Stainless Steel UFO Beads 3.5mm

SSUFO35 1pack
EUR 229.2
Description: Stainless steel UFO beads. 3.5mm. 50mL. Non-sterile.

Stainless Steel UFO Beads 5.6mm

SSUFO56 1pack
EUR 225.6
Description: Stainless steel UFO beads. 5.6mm. 50mL. Non-sterile.

Raf-1 RBD Agarose Beads

STA-410 400 ?g
EUR 686.4
Description: Raf-1 RBD Agarose Beads selectively pull down the active form of Ras. Beads are colored to allow for a visual check. These are the same beads supplied with our Ras Activation Assays. 400 µg.

Flexi-Block + Beads Double Width

BLO2162 EACH
EUR 283.86

Flexi-Block + Beads Triple Width

BLO2163 EACH
EUR 428.64

500GM Glass beads 2mm 500gm

GS/2 500G
EUR 15.28

We subsequently screened a human Area Antibody library in opposition to CSF114(Glc) utilizing magnetic separation as a panning methodology. We obtained and described a number of clones, and the one with the very best indicators was produced as a 6×His-tagged protein to correctly examine the binding properties as a soluble antibody.

Leave a Reply

Your email address will not be published. Required fields are marked *