The glycan role in the glycopeptide immunogenicity revealed by atomistic simulations and spectroscopic experiments on the multiple sclerosis biomarker CSF114(Glc).

The glycan role in the glycopeptide immunogenicity revealed by atomistic simulations and spectroscopic experiments on the multiple sclerosis biomarker CSF114(Glc).

Glycoproteins are sometimes acknowledged as not-self molecules by antibodies triggering the onset of extreme autoimmune illnesses resembling A number of Sclerosis (MS). Thus, the event of antigen-mimicking biomarkers represents a sexy technique for an early analysis of the illness. An instance is the artificial glycopeptide CSF114(Glc), which was designed and examined as MS biomarker and whose scientific utility was restricted by its diminished capability to detect autoantibodies in MS sufferers. Within the try to enhance the efficacy of CSF114(Glc), we’ve characterised all of the occasions resulting in the ultimate binding of the biomarker to the autoantibody utilizing atomistic simulations, ESR and NMR experiments. The glycosydic moiety performs a major function in the entire course of.

Particularly, in an setting mimicking that used within the scientific checks the glycopeptide assumes a α-helix construction that’s useful for the interplay with the antibody. On this conformation CSF114(Glc) binds the monoclonal antibody mAb8-18C5 equally to the myelin oligodendrocyte glycoprotein MOG, which is a identified MS auto-antigen, thus explaining its diagnostic exercise. Our examine provides new molecular bases to design more practical biomarkers and offers a most legitimate protocol to analyze different methods the place the setting impact is determinant for the organic exercise.

The current examine was carried out to look at the dissipation sample of triazophos on capsicum and danger evaluation of its residues on human beings and to recommend a ready interval for the protection of customers. Following two functions of triazophos (Truzo 40 EC) at 500 and 1000 g a.i. ha(-1), the typical preliminary deposits had been discovered to be 3.61 and 6.26 mg kg(-1), respectively. These residues dissipated beneath the restrict of quantification (LOQ) of 0.05 mg kg(-1) in 10 and 15 days on the beneficial and double the beneficial dosages, respectively. The calculated values of half-life had been 2.31 and a couple of.

14 days at beneficial and double the beneficial dosages, respectively. Theoretical most residue contribution (TMRC) values had been discovered to be 28.eight and 41.6 μg individual(-1) day(-1) at 500 and 1000 g a.i. ha(-1), respectively, and located to be beneath the utmost permissible consumption on capsicum fruit on the seventh day. Subsequently, a ready interval of seven days is recommended for consumption of capsicum sprayed with triazophos on the beneficial dosages.

Preliminary examine on utility of urine amino acids profiling for monitoring of renal tubular damage utilizing GLC-MS.

The early analysis of the nephrotoxic impact of xenobiotics and medicines remains to be an unsolved drawback. Current research recommend a correlation between the nephrotoxic exercise of xenobiotics and elevated focus of amino acids in urine. The introduced examine was targeted on the applying of GLC-MS methodology for amino acids profiling in human urine as a noninvasive methodology for monitoring of kidney situation and tubular damage degree.
The analytic methodology relies on the conversion of the amino acids current within the pattern to tert-butyldimethylsilyl (TBDMS) derivatives and their evaluation by gas-liquid chromatography-mass spectrometry (GLC-MS). The process of urine pattern preparation for chromatographic evaluation was optimized. CSF114(Glc) is an artificial glucopeptide detecting in vitro MS-specific auto-antibodies, and it’s actively utilized in diagnostics and analysis to observe and quantify MS-associated Ig ranges.
The presence of 12 amino acids in a lot of the examined wholesome human urine samples was detected. The numerous variations within the ranges of specific amino acids between sufferers with tubular damage and wholesome controls had been discovered, particularly for lysine, valine, serine, alanine and leucine. We discovered that this strategy based mostly on GLC-MS detection can be utilized in nephrotoxicity research for urine amino acids monitoring in publicity to xenobiotics and medicines.
The glycan role in the glycopeptide immunogenicity revealed by atomistic simulations and spectroscopic experiments on the multiple sclerosis biomarker CSF114(Glc).

A easy methodology for isolation and purification of DIBOA-Glc from Tripsacum dactyloides.

Naturally occurring benzoxazinones (Bx) are a extremely reactive class of compounds which have obtained specific consideration prior to now a number of many years. Lately, we recognized 2-β-D-glucopyranosyloxy-4-hydroxy-1,4-benzoxazin-3-one (DIBOA-Glc) because the compound current within the roots of Japanese gamagrass {Tripsacum dactyloides (L.)} accountable for atrazine degradation. Nonetheless, characterization of the DIBOA-Glc/atrazine degradation response has been restricted on account of difficulties achieve ample portions of purified DIBOA-Glc.

The target of the examine was to develop a easy purification and isolation methodology for acquiring bulk portions of extremely purified DIBOA-Glc. T. dactyloides roots had been extracted with 90% aqueous methanol, and the crude extract was fractionated utilizing an HPLC geared up with a C8 semi-prep column and fraction collector. UHPLC-DAD-MS/MS was used to verify the identification of DIBOA-Glc within the fractions collected. Evaluation by 13C and 1H NMR and DAD indicated that 542 mg of DIBOA-Glc with a purity of>> 99% was obtained.

The reactivity of the DIBOA-Glc was confirmed in a 16 hour assay with atrazine, which resulted in 48.5% ± 1.2% (SD) atrazine degradation. The tactic described right here provides a number of benefits over present extraction and synthesis strategies, that are extra cumbersome, use hazardous chemical compounds, and yield solely small portions of purified compound. The newly developed methodology will facilitate future analysis characterizing the chemical conduct of DIBOA-Glc and decide its potential as an atrazine mitigation and remediation software.

Human recombinant area antibodies in opposition to a number of sclerosis antigenic peptide CSF114(Glc).

A number of sclerosis (MS) is a power auto-immune illness characterised by a injury to the myelin part of the central nervous system. Self-antigens created by aberrant glycosylation have been described to be a key part within the formation of auto-antibodies.  We reasoned that antibodies raised in opposition to this probe may have been related for MS.

Anti-HA magnetic beads

B26202 5 mL
EUR 1742.4
Description: Anti-HA magnetic beads kit is based on hydroxyl magnetic beads covalently coupling with high quality mouse IgG2b monoclonal antibody, used for co-immunoprecipitation and protein purification.

Anti-HA Magnetic Beads

HY-K0201 1 mL
EUR 334.8

Anti-Myc magnetic beads

B26301 1 mL
EUR 579.6
Description: Anti-Myc magnetic beads kit is based on hydroxyl magnetic beads covalently coupling with mouse IgG1 monoclonal antibody.it is recommended to use for co-immunoprecipitation and protein purification.

Anti-Myc magnetic beads

B26302 5 mL
EUR 1742.4
Description: Anti-Myc magnetic beads kit is based on hydroxyl magnetic beads covalently coupling with mouse IgG1 monoclonal antibody.it is recommended to use for co-immunoprecipitation and protein purification.

Protein A Magnetic Beads

6507-1 each
EUR 314.4

Protein G Magnetic Beads

6517-1 each
EUR 314.4

Protein L Magnetic Beads

6537-1 each
EUR 352.8

Protein A Magnetic Beads

HY-K0203 1 mL
EUR 148.8

Protein G Magnetic Beads

HY-K0204 5 mL
EUR 445.2

Anti-Flag magnetic beads

B26101 1 mL
EUR 579.6
Description: Anti-Flag magnetic beads is based on hydroxyl magnetic beads covalently coupling with mouse IgG1 monoclonal antibody. It is recommended to use for co-immunoprecipitation and protein purification.

Anti-Flag magnetic beads

B26102 5 mL
EUR 1742.4
Description: Anti-Flag magnetic beads is based on hydroxyl magnetic beads covalently coupling with mouse IgG1 monoclonal antibody. It is recommended to use for co-immunoprecipitation and protein purification.

Anti-Flag Magnetic Beads

HY-K0207 1 mL
EUR 570

BlackPearl® (Magnetic Beads)

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BlackPearl® (Magnetic Beads)

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BlackPearl® (Magnetic Beads)

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Magnetic Beads™ Streptavidin

SMB-B01 5mg
EUR 246.1
Description: The Streptavidin-Magnetic Beads are 2.8 µm superparamagnetic particles covalently coupled to a highly pure form of streptavidin (SA). The beads can be used to capture the biotinylated proteins or other molecules, because Streptavidin (SA) has an extraordinarily high affinity for biotin with a dissociation constant (Kd) on the order of 10−14 mol/L, the Biotinylated molecules can bind to the SA irreversibly.Streptavidin is a tetrameric protein purified from the bacterium Streptomyces avidin, and exhibits high binding affinity for biotin. Able to bind one molecule of biotin with each subunit. Streptavidin (PI=6.0-7.5) has lower level of non-specific binding to various biological components at physiological pH than avidin (PI=7.4), resulting from its isoelectric point (PI).The Streptavidin-Magnetic Beads is easy to capture the biotinylated proteins or other molecules in Chemiluminescence procedures, and the bounded protein have no activity lost, this ready to use products could greatly save your protein coupling time and hassle, and help us get the best performance and highly reproducible results.

Protein A/G Magnetic Beads

6527-1 each
EUR 352.8

Protein A/G Magnetic Beads

HY-K0202 1 mL
EUR 157.2

Anti-c-Myc Magnetic Beads

HY-K0206 5 mL
EUR 1368

Anti-HA (Nanobody) Magnetic Beads

AE109 500μL
EUR 403

Anti-GFP (Nanobody) Magnetic Beads

AE079 500μL
EUR 312

Anti-Myc (Nanobody) Magnetic Beads

AE107 1000μL
EUR 213.2

Protein A/G/L Magnetic Beads

6547-1 each
EUR 405.6

Human CD33-coupled Magnetic Beads

MBC-K008 2mg
EUR 2707.1
Description: Human CD33 protein is expressed from human 293 cells (HEK293). It contains AA Asp 18 - His 259(Accession # P20138-1(R69G)).

Human CD38-coupled Magnetic Beads

MBC-K010 2mg
EUR 2707.1
Description: Human CD38 protein is expressed from human 293 cells (HEK293). It contains AA Val 43 - Ile 300(Accession # P28907-1).

Human EGFR-coupled Magnetic Beads

MBE-K012 2mg
EUR 2707.1
Description: Human EGFR protein is expressed from human 293 cells (HEK293). It contains AA Leu 25 - Ser 645(Accession # P00533-1).

Human PSMA-coupled Magnetic Beads

MBP-K007 2mg
EUR 3349.1
Description: Human PSMA protein is expressed from human 293 cells (HEK293). It contains AA Lys 44 - Ala 750(Accession # Q04609-1).

Human ROR1-coupled Magnetic Beads

MBR-K009 2mg
EUR 2707.1
Description: Human ROR1 protein is expressed from human 293 cells (HEK293). It contains AA Gln 30 - Glu 403(Accession # Q01973-1).

Human BCMA-coupled Magnetic Beads

MBS-K004 2mg
EUR 2707.1
Description: Human BCMA protein is expressed from human 293 cells (HEK293). It contains AA Met 1 - Ala 54(Accession # Q02223-1).

Human CD19-coupled Magnetic Beads

MBS-K005 2mg
EUR 4312.1
Description: Human CD19 protein is expressed from human 293 cells (HEK293). It contains AA Pro 20 - Lys 291(Accession # P15391-1).

Human HER2-coupled Magnetic Beads

MBS-K006 500ug
EUR 2835.5
Description: Human HER2 protein is expressed from human 293 cells (HEK293). It contains AA Thr 23 - Thr 652(Accession # P04626-1).

Human ACE2-coupled Magnetic Beads

MBS-K013 2mg
EUR 2707.1
Description: Human ACE2 protein is expressed from human 293 cells (HEK293). It contains AA Gln 18 - Ser 740(Accession # Q9BYF1-1).

Human CD73-coupled Magnetic Beads

MBS-K022 2mg
EUR 3349.1
Description: Human CD73 Protein is expressed from human 293 cells (HEK293). It contains AA Trp 27 - Ser 549(Accession # P21589-1).

Human CD47-coupled Magnetic Beads

MBS-K023 2mg
EUR 2707.1
Description: Human CD47 Protein is expressed from human 293 cells (HEK293). It contains AA Gln 19 - Pro 139(Accession # Q08722).

Human CD3E-coupled Magnetic Beads

MBS-K026 2mg
EUR 2707.1
Description: Human CD3E Protein is expressed from human 293 cells (HEK293). It contains AA Asp 23 - Asp 126(Accession # P07766-1).

Human CD22-coupled Magnetic Beads

MBS-K052 2mg
EUR 4312.1
Description: Human CD22 Protein is expressed from human 293 cells (HEK293). It contains AA Asp 20 - Arg 687(Accession # P20273-1).

Human DLL3-coupled Magnetic Beads

MBS-K053 2mg
EUR 2707.1
Description: Delta-like protein 3 (DLL3) is a transmembrane protein that belongs to the Delta/Serrate/Lag-2 (DSL) family of Notch ligands.May be required to divert neurons along a specific differentiation pathway. Plays a role in the formation of somite boundaries during segmentation of the paraxial mesoderm. DLL3 protein is expressed on the surface of tumor cells but not in normal adult tissues.

Human uPAR-coupled Magnetic Beads

MBS-K076 2mg
EUR 2707.1
Description: Tumors are the result of uncontrolled proliferation of cells in different organs. Tumor development is a multistage process, that includes the generation of primary tumors, separation of tumors from primary sites, degradation of extracellular matrix (ECM), and distant metastasis of tumors. A variety of genes play important roles in the development of tumors, including the cell surface receptor urokinase-type plasminogen activator receptor (uPAR). uPAR is highly expressed in a variety of tumor cells, and a variety of signals regulated by uPAR play significant roles in tumor cell proliferation and metastasis, tumor-related glycolysis, the tumor microenvironment and angiogenesis. Studies have found that some specific drugs and antibodies have unique inhibitory effects on uPAR.

Human PCSK9-coupled Magnetic Beads

MBS-K054 2mg
EUR 2707.1
Description: Proprotein convertase subtilisin/kexin type 9 (PCSK9) is also known as NARC1 (neural apoptosis regulated convertase), is a newly identified subtilase belonging to the peptidase S8 subfamily. Mouse PCSK9 is synthesized as a soluble zymogen, and undergoes autocatalytic intramolecular processing in the endoplasmic reticulum, resulting in the cleavage of its propeptide that remains associated with the secreted active enzyme with a broad alkaline pH optimum. This protein plays a major regulatory role in cholesterol homeostasis. PCSK9 binds to the epidermal growth factor-like repeat A (EGF-A) domain of the low-density lipoprotein receptor (LDLR), inducing LDLR degradation. PCSK9 may also have a role in the differentiation of cortical neurons. Mutations in this gene have been associated with a rare form of autosomal dominant familial hypercholesterolemia (HCHOLA3).

Human ASGR1-coupled Magnetic Beads

MBS-K055 2mg
EUR 2707.1
Description: ASGPR, a transmembrane C-type lectin, recognizes a wide variety of ligands that contain either terminal galactose (Gal) or N-acetylgalactosamine (GalNAc) residues and has been identified as a highly selective receptor on hepatocytes. The ASGR is composed of both a major (ASGR1) and minor subunit (ASGR2). ASGR1 has been shown to be efficiently targeted to the plasma membrane and to undergo constitutive endocytosis and recycling and found mainly expressed in the human liver.

Amylose BlackPearl® (Magnetic Beads)

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Amylose BlackPearl® (Magnetic Beads)

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Human ANGPT2-coupled Magnetic Beads

MBS-K035 2mg
EUR 2707.1
Description: Human ANGPT2 Protein is expressed from human 293 cells (HEK293). It contains AA Lys 275 - Phe 496(Accession # O15123-1).

Human VEGF165-coupled Magnetic Beads

MBS-K036 2mg
EUR 2707.1
Description: Human VEGF165 Protein is expressed from human 293 cells (HEK293). It contains AA Ala 27 - Arg 191(Accession # P15692-4).

Human EGFRvIII-coupled Magnetic Beads

MBS-K020 2mg
EUR 2707.1
Description: Human EGFRvIII Protein is expressed from human 293 cells (HEK293). It contains AA Leu 25- Ser 378(Accession # NP_001333870.1).

Human HGF R-coupled Magnetic Beads

MBS-K021 2mg
EUR 2707.1
Description: Human HGF R Protein is expressed from human 293 cells (HEK293). It contains AA Glu 25 - Thr 932(Accession # P08581).

Human CTLA-4 coupled Magnetic Beads

MBS-K042 2mg
EUR 2707.1
Description: Human CTLA-4 Protein is expressed from human 293 cells (HEK293). It contains AA Ala 37 - Phe 162(Accession # Q6GR94-1).

Human Mesothelin-coupled Magnetic Beads

MBS-K024 2mg
EUR 2707.1
Description: Human Mesothelin Protein is expressed from human 293 cells (HEK293). It contains AA Glu 296 - Gly 580(Accession # Q13421-3(R309P)).

Streptavidin BlackPearl® (Magnetic Beads)

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Streptavidin BlackPearl® (Magnetic Beads)

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Protein A/G Magnetic Beads for IP

B23201 1 ml
EUR 158.4
Description: Protein A/G Magnetic Beads for immunoprecipitation (IP) are based on a biological nanosurface technology (S-TEC). Protein A/G coats the surface of super paramagnetic microspheres with high coating density up to 9.3 × 10^13 molecules/cm2. Compared to similar immune magnetic beads, our Protein A/G beads display much more antibody binding sites therefore using less magnetic beads per reaction and ultimately achiving greater cost-efficiency. Non-specific binding is reduced to an absolute low eliminating any detectable interference with your IP assays. The large, specific surface area of the beads greatly shortens the adsorption time and achieves complete antibody/antigen adsorption process in 10 minutes and complete total purification and precipitation in just 30 minutes. This product can be used on a wide variety of samples, such as in cell lysates, supernatants collected from cell secretion, serum, ascites, and other immune antigens.

Protein A/G Magnetic Beads for IP

B23202 5 ml
EUR 558
Description: Protein A/G Magnetic Beads for immunoprecipitation (IP) are based on a biological nanosurface technology (S-TEC). Protein A/G coats the surface of super paramagnetic microspheres with high coating density up to 9.3 × 10^13 molecules/cm2. Compared to similar immune magnetic beads, our Protein A/G beads display much more antibody binding sites therefore using less magnetic beads per reaction and ultimately achiving greater cost-efficiency. Non-specific binding is reduced to an absolute low eliminating any detectable interference with your IP assays. The large, specific surface area of the beads greatly shortens the adsorption time and achieves complete antibody/antigen adsorption process in 10 minutes and complete total purification and precipitation in just 30 minutes. This product can be used on a wide variety of samples, such as in cell lysates, supernatants collected from cell secretion, serum, ascites, and other immune antigens.

Human TROP-2-coupled Magnetic Beads

MBS-K028 2mg
EUR 2707.1
Description: Human TROP-2 Protein is expressed from human 293 cells (HEK293). It contains AA Gln 31 - Thr 274(Accession # P09758-1).

Protein A BlackPearl® (Magnetic Beads)

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Protein A BlackPearl® (Magnetic Beads)

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Protein A BlackPearl® (Magnetic Beads)

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Protein G BlackPearl® (Magnetic Beads)

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Protein G BlackPearl® (Magnetic Beads)

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Nickel (Ni2+) BlackPearl® (Magnetic Beads)

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Nickel (Ni2+) BlackPearl® (Magnetic Beads)

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Human Nectin-4-coupled Magnetic Beads

MBS-K039 2mg
EUR 2707.1
Description: Human Nectin-4 Protein is expressed from human 293 cells (HEK293). It contains AA Gly 32 - Ser 349(Accession # Q96NY8-1).

Anti-mCherry (Nanobody) Magnetic Beads Ab

AE094 1000μL
EUR 213.2

Human B7-H3(4Ig)-coupled Magnetic Beads

MBS-K040 2mg
EUR 2707.1
Description: Human B7-H3 Protein is expressed from human 293 cells (HEK293). It contains AA Gly 27 - Thr 461(Accession # Q5ZPR3-1).

Calmodulin (CAM) BlackPearl® (Magnetic Beads)

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Calmodulin (CAM) BlackPearl® (Magnetic Beads)

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Calmodulin (CAM) BlackPearl® (Magnetic Beads)

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Glutathione (GSH) BlackPearl® (Magnetic Beads)

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Glutathione (GSH) BlackPearl® (Magnetic Beads)

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Glutathione (GSH) BlackPearl® (Magnetic Beads)

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Universal IP/Co-IP Toolkit (Magnetic Beads)

KTD104-EN-20T 20 T
EUR 169
Description: Antibody coupling magnetic beads, suitable for IP/ CO-IP experiment, protein purification.

PE-labeled Human CD47-coupled Magnetic Beads

MBS-K059 2.5mg
EUR 4536.8
Description: Leukocyte surface antigen CD47 is also known as Antigenic surface determinant protein OA3, Integrin-associated protein (IAP) and Protein MER6. CD47 contains 1 Ig-like V-type (immunoglobulin-like) domain. CD47 is very broadly distributed on normal adult tissues. CD47 has a role in both cell adhesion by acting as an adhesion receptor for THBS1 on platelets, and in the modulation of integrins and plays an important role in memory formation and synaptic plasticity in the hippocampus by similarity. CD47 is the receptor for SIRPA, binding to which prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells. CD47 Interaction with SIRPG mediates cell-cell adhesion, enhances superantigen-dependent T-cell-mediated proliferation and costimulates T-cell activation.

APC-labeled Human CD47-coupled Magnetic Beads

MBS-K060 0.5mg
EUR 3028.1
Description: Leukocyte surface antigen CD47 is also known as Antigenic surface determinant protein OA3, Integrin-associated protein (IAP) and Protein MER6. CD47 contains 1 Ig-like V-type (immunoglobulin-like) domain. CD47 is very broadly distributed on normal adult tissues. CD47 has a role in both cell adhesion by acting as an adhesion receptor for THBS1 on platelets, and in the modulation of integrins and plays an important role in memory formation and synaptic plasticity in the hippocampus by similarity. CD47 is the receptor for SIRPA, binding to which prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells. CD47 Interaction with SIRPG mediates cell-cell adhesion, enhances superantigen-dependent T-cell-mediated proliferation and costimulates T-cell activation.

SARS-CoV-2 Spike S1-coupled Magnetic Beads

MBS-K001 2mg
EUR 2707.1
Description: SARS-CoV-2 Spike S1 protein is expressed from human 293 cells (HEK293). It contains AA Val 16 - Arg 685(Accession # QHD43416.1).

SARS-CoV-2 Spike S2-coupled Magnetic Beads

MBS-K018 2mg
EUR 2707.1
Description: SARS-CoV-2 Spike S2 Protein is expressed from human 293 cells (HEK293). It contains AA Ser 686 - Pro 1213 (Accession # QHD43416.1 (F817P, A892P, A899P, A942P,K986P,V987P)).

SARS-CoV-2 Spike RBD-coupled Magnetic Beads

MBS-K002 2mg
EUR 2707.1
Description: SARS-CoV-2 Spike RBD protein is expressed from human 293 cells (HEK293). It contains AA Arg 319 - Phe 541(Accession # QHD43416.1).

SARS-CoV-2 Spike NTD-coupled Magnetic Beads

MBS-K019 2mg
EUR 2707.1
Description: SARS-CoV-2 Spike NTD Protein is expressed from human 293 cells (HEK293). It contains AA Val 16 - Phe 318(Accession # QHD43416.1).

Human CD3E & CD3D Heterodimer-coupled Magnetic Beads

MBS-K003 2mg
EUR 2707.1
Description: Human CD3E & CD3D Heterodimer protein is expressed from human 293 cells (HEK293).It contains AA Asp 23 - Asp 126 (CD3E) & Phe 22 - Ala 105 (CD3D) (Accession # P07766-1(CD3E) & P04234-1(CD3D)).

Magnetic Beads-conjugated Rabbit IgG isotype control

AC047 100μL
EUR 87.75
Description: None

SARS-CoV-2 Spike Trimer-coupled Magnetic Beads

MBS-K015 2mg
EUR 4312.1
Description: SARS-CoV-2 Spike Trimer protein is expressed from human 293 cells (HEK293). It contains AA Val 16 - Pro 1213(Accession # QHD43416.1 (R683A, R685A)).

Magnetic Beads-conjugated Mouse anti DDDDK-Tag mAb

AE037 50 ul
EUR 211.2

Magnetic Beads-conjugated Rabbit anti DDDDK-Tag mAb

AE097 1000μL
EUR 84.5

SARS-CoV-2 Spike RBD (B.1.351) Coupled Magnetic Beads

MBS-K032 2mg
EUR 2707.1
Description: SARS-CoV-2 Spike RBD (B.1.351) Protein is expressed from human 293 cells (HEK293). It contains AA Arg 319 - Lys 537(Accession # QHD43416.1 (K417N,E484K,N501Y)).

SARS-CoV-2 Spike RBD (P.1) Coupled Magnetic Beads

MBS-K033 2mg
EUR 2707.1
Description: SARS-CoV-2 Spike RBD (P.1) Protein is expressed from human 293 cells (HEK293). It contains AA Arg 319 - Lys 537(Accession # QHD43416.1 (K417T,E484K,N501Y)).

SARS-CoV-2 Spike RBD (B.1.1.7) Coupled Magnetic Beads

MBS-K034 2mg
EUR 2707.1
Description: SARS-CoV-2 Spike RBD (B.1.1.7) Protein is expressed from human 293 cells (HEK293). It contains AA Arg 319 - Lys 537(Accession # QHD43416.1(N501Y)).

resDetect™ resDNA Sample Preparation Kit (Magnetic Beads)

OPA-R005 50preps
EUR 310.3
Description: DNA extraction is a critical step in many molecular biology techniques, such as PCR, sequencing, and cloning, as it is necessary to obtain pure and intact DNA that can be used in downstream applications. DNA extraction kits can simplify and standardize the DNA extraction process, allowing researchers to obtain high-quality DNA from a wide range of samples with reproducible results.

Protein A-coupled Magnetic Beads (recommended for MPCLIA)

MPC-A001 10mg
EUR 866.7
Description: The Protein A-coupled Magnetic Beads are 2.8 µm superparamagnetic particles covalently coupled to a highly pure form of protein A. The beads can be used to capture the antibodies in Chemiluminescence procedures.The Protein A is a 42 kDa surface protein, It binds the heavy chain within the Fc region of most immunoglobulins and also within the Fab region in the case of the human VH3 family.The Anti-Protein A-coupled Magnetic Beads is easy to capture the antibodies, and the bounded antibody have no activity lost, this ready to use products could greatly save your protein coupling time and hassle, and help us get the best performance and highly reproducible results.

Protein G-coupled Magnetic Beads (recommended for MPCLIA)

MPC-A002 10mg
EUR 866.7
Description: The Protein G-coupled Magnetic Beads are 2.8 µm superparamagnetic particles covalently coupled to a highly pure form of protein G. The beads can be used to capture the antibodies in Chemiluminescence procedures.The Protein G binds the heavy chain within the Fc region of most immunoglobulins but not bind dog immunoglobulins.The Protein G-coupled Magnetic Beads is easy to capture the most antibodies, and the bounded antibody have no activity lost, this ready to use products could greatly save your protein coupling time and hassle, and help us get the best performance and highly reproducible results.

Protein L-coupled Magnetic Beads (recommended for MPCLIA)

MPC-A008 10mg
EUR 866.7
Description: The Protein L-coupled Magnetic Beads are 2.8 µm superparamagnetic particles covalently coupled to a highly pure form of Protein L. The beads can be used to capture the antibodies in Chemiluminescence procedures. The Protein L is a 45 kDa surface protein, and can bind almost all antibody types, including IgG, IgM, IgA, IgE and IgD. It binds to antibodies with appropriate Kappa light chains such as VkI, VkIII and VkIV, whereas no binding occurred with antibodies of the VkII or with any Lambda light chains. The Protein L-coupled Magnetic Beads is easy to capture the most antibodies, and the bounded antibody have no activity lost, this ready to use products could greatly save your protein coupling time and hassle, and help us get the best performance and highly reproducible results.

SARS-CoV-2 (Delta) Spike RBD-coupled Magnetic Beads

MBS-K037 2mg
EUR 2707.1
Description: SARS-CoV-2 (Delta) Spike RBD Protein is expressed from human 293 cells (HEK293). It contains AA Arg 319 - Lys 537(Accession # QHD43416.1 (L452R, T478K)).

Universal IP/Co-IP Toolkit (Magnetic Beads/Anti-Mouse)

KTI1010-EN-20T 20 T
EUR 139
Description: Antibody coupling magnetic beads, suitable for IP/ CO-IP experiment, protein purification.

SARS-CoV-2 Spike Trimer (D614G)-coupled Magnetic Beads

MBS-K016 2mg
EUR 4312.1
Description: SARS-CoV-2 Spike Trimer (D614G) protein is expressed from human 293 cells (HEK293). It contains AA Val 16 - Pro 1213(Accession # QHD43416.1 (D614G, R683A, R685A)).

Universal IP/Co-IP Toolkit (Magnetic Beads/Anti-Rabbit)

KTI1020-EN-20T 20 T
EUR 139
Description: Antibody coupling magnetic beads, suitable for IP/ CO-IP experiment, protein purification.

SARS-CoV-2 (Omicron) Spike RBD-coupled Magnetic Beads

MBS-K043 2mg
EUR 2707.1
Description: SARS-CoV-2 (Omicron) Spike RBD Protein is expressed from human 293 cells (HEK293). It contains AA Arg 319 - Lys 537(Accession # QHD43416.1 (G339D, S371L, S373P, S375F, K417N, N440K, G446S, S477N, T478K, E484A, Q493K, G496S, Q498R, N501Y, Y505H)).

SARS-CoV-2 Spike Trimer (B.1.1.7) Coupled Magnetic Beads

MBS-K029 2mg
EUR 2707.1
Description: SARS-CoV-2 Spike Trimer (B.1.1.7) Protein is expressed from human 293 cells (HEK293). It contains AA Val 16 - Pro 1213(Accession # QHD43416.1 (HV69-70del/Y144del//N501Y/A570D/D614G/P681H/T716I/S982A/D1118H/R683A/R685A/F817P/A892P/A899P/A942P/K986P/V987P)).

SARS-CoV-2 Spike Trimer (B.1.351) Coupled Magnetic Beads

MBS-K030 2mg
EUR 2707.1
Description: SARS-CoV-2 Spike Trimer (B.1.351) Protein is expressed from human 293 cells (HEK293). It contains AA Val 16 - Pro 1213(Accession # QHD43416.1 (L18F, D80A, D215G, 242-244del, R246I, K417N, E484K, N501Y, D614G, A701V, R683A, R685A,F817P, A892P, A899P, A942P, K986P, V987P)).

SARS-CoV-2 Spike Trimer (P.1) Coupled Magnetic Beads

MBS-K031 2mg
EUR 2707.1
Description: SARS-CoV-2 Spike Trimer (P.1) Protein is expressed from human 293 cells (HEK293). It contains AA Val 16 - Pro 1213(Accession # QHD43416.1 (L18F, T20N, P26S, D138Y, R190S, K417T, E484K, N501Y, D614G, H655Y, T1027I, V1176F, R683A, R685A,F817P, A892P, A899P, A942P, K986P, V987P)).

SARS-CoV-2 Nucleocapsid Protein-coupled Magnetic Beads

MBS-K017 2mg
EUR 2707.1
Description: SARS-CoV-2 Nucleocapsid Protein is expressed from human 293 cells (HEK293). It contains AA Met 1 - Ala 419(Accession # QHO62115.1).

SARS-CoV-2 (Delta) Spike Trimer-coupled Magnetic Beads

MBS-K038 2mg
EUR 4312.1
Description: SARS-CoV-2 (Delta) Spike Trimer Protein is expressed from human 293 cells (HEK293). It contains AA Arg 319 - Lys 537(Accession # QHD43416.1 (T19R, G142D, EF156-157del, R158G, L452R, T478K, D614G, P681R, D950N, R683A, R685A, F817P, A892P, A899P, A942P, K986P, V987P)).

Anti-Mouse IgG-coupled Magnetic Beads (recommended for MPCLIA)

MPC-A003 10mg
EUR 1305.4
Description: The Anti-Mouse IgG-coupled Magnetic Beads are 2.8 µm superparamagnetic particles covalently coupled to a highly affinity polyclonal goat anti-mouse IgG antibody. The beads can be used to capture the mouse IgG in Chemiluminescence procedures.The antibody reacts with the Fc or Fab portion of mouse IgG. No antibody was detected against mouse IgM or IgA, or against non-immunoglobulin serum proteins. The antibody has been tested by ELISA and/or solid-phase adsorbed to ensure minimal cross-reaction with bovine serum proteins, but it may cross-react with immunoglobulins from other species.The Anti-Mouse IgG-coupled Magnetic Beads is easy to capture the mouse IgG, and the bounded protein have no activity lost, this ready to use products could greatly save your protein coupling time and hassle, and help us get the best performance and highly reproducible results.

Anti-Human IgG-coupled Magnetic Beads (recommended for MPCLIA)

MPC-A004 10mg
EUR 984.4
Description: The Anti-Human IgG-coupled Magnetic Beads are 2.8 µm superparamagnetic particles covalently coupled to a highly affinity Monoclonal mouse anti-human IgG antibody. The beads can be used to capture the human IgG in Chemiluminescence procedures.The antibody reacts with the Fc portion of human IgG heavy chain but not with the Fab portion of human IgG. No antibody was detected against human IgM or IgA, or against non-immunoglobulin serum proteins. The antibody has been tested by ELISA and/or solid-phase adsorbed to ensure minimal cross-reaction with mouse, cynomolgus and bovine serum proteins, but it is not sure if the product cross-react with immunoglobulins from other species.The Anti-Human IgG-coupled Magnetic Beads is easy to capture the human IgG, and the bounded antibody have no activity lost, this ready to use products could greatly save your protein coupling time and hassle, and help us get the best performance and highly reproducible results.

Anti-Human IgM-coupled Magnetic Beads (recommended for MPCLIA)

MPC-A010 100mg
EUR 107
Description: The Anti-Human IgM-coupled Magnetic Beads are 2.8 µm superparamagnetic particles covalently coupled to a highly affinity Monoclonal anti-human IgM antibody. The beads can be used to capture the Human IgM in Chemiluminescence procedures. It has no-corss-reactivity with Human IgG, IgA or IgE. The Anti-Human IgM-coupled Magnetic Beads is easy to capture the human IgM, and the bounded antibody have no activity lost, this ready to use products could greatly save your protein coupling time and hassle, and help us get the best performance and highly reproducible results.

RNA/DNA Purification Kit (Magnetic Bead)

DA0623 32 test/kit Ask for price

Magnetic Beads Conjugated Anti-GFP Tag Mouse Monoclonal Antibody (3D3)

ABT2024-1mL 1 mL
EUR 279
Description: Featured Anti-GFP Tag Mouse Monoclonal Antibody, Magnetic Beads, specially designed for immunoprecipitation (IP) of your tagged protein.

Magnetic Beads Conjugated Anti-GFP Tag Mouse Monoclonal Antibody (3D3)

ABT2024-5mL 5 mL
EUR 969
Description: Featured Anti-GFP Tag Mouse Monoclonal Antibody, Magnetic Beads, specially designed for immunoprecipitation (IP) of your tagged protein.

Magnetic Beads Conjugated Anti-HA Tag Mouse Monoclonal Antibody (4F6)

ABT2044-1mL 1 mL
EUR 279
Description: Featured Anti-HA Tag Mouse Monoclonal Antibody, Magnetic Beads, specially designed for immunoprecipitation (IP) of your tagged protein.

Magnetic Beads Conjugated Anti-HA Tag Mouse Monoclonal Antibody (4F6)

ABT2044-5mL 5 mL
EUR 969
Description: Featured Anti-HA Tag Mouse Monoclonal Antibody, Magnetic Beads, specially designed for immunoprecipitation (IP) of your tagged protein.

Magnetic Beads Conjugated Anti-His Tag Mouse Monoclonal Antibody (5C3)

ABT2054-1mL 1 mL
EUR 279
Description: Featured Anti-His Tag Mouse Monoclonal Antibody, Magnetic Beads, specially designed for immunoprecipitation (IP) of your tagged protein.

Magnetic Beads Conjugated Anti-His Tag Mouse Monoclonal Antibody (5C3)

ABT2054-5mL 5 mL
EUR 969
Description: Featured Anti-His Tag Mouse Monoclonal Antibody, Magnetic Beads, specially designed for immunoprecipitation (IP) of your tagged protein.

Magnetic Beads Conjugated Anti-Myc Tag Mouse Monoclonal Antibody (2D5)

ABT2064-1mL 1 mL
EUR 279
Description: Featured Anti-Myc Tag Mouse Monoclonal Antibody, Magnetic Beads, specially designed for immunoprecipitation (IP) of your tagged protein.

Magnetic Beads Conjugated Anti-Myc Tag Mouse Monoclonal Antibody (2D5)

ABT2064-5mL 5 mL
EUR 969
Description: Featured Anti-Myc Tag Mouse Monoclonal Antibody, Magnetic Beads, specially designed for immunoprecipitation (IP) of your tagged protein.

Magnetic Beads Conjugated Anti-V5 Tag Mouse Monoclonal Antibody (11D5)

ABT2174-1mL 1 mL
EUR 279
Description: Featured Anti-V5 Tag Mouse Monoclonal Antibody, Magnetic Beads, specially designed for immunoprecipitation (IP) of your tagged protein.

Magnetic Beads Conjugated Anti-V5 Tag Mouse Monoclonal Antibody (11D5)

ABT2174-5mL 5 mL
EUR 969
Description: Featured Anti-V5 Tag Mouse Monoclonal Antibody, Magnetic Beads, specially designed for immunoprecipitation (IP) of your tagged protein.

Human Anti-SARS-CoV-2 Spike RBD Antibody-coupled Magnetic Beads

MBS-K014 2mg
EUR 2707.1
Description: The Human Anti-SARS-CoV-2 Spike RBD Antibody-coupled Magnetic Beads is produced by coupling biotinylated anti-RBD antibody to streptavidin-conjugated magnetic beads. The pre-coupled beads are ready to use for capturing spike protein from your sample with high specificity. The uniform size and large surface-to-volume ratio of the beads ensure highly efficent immunocapture in a simple, fast and convenient workflow with high reproducibilty of data.

Magnetic Beads Conjugated Anti-DDDDK Tag Mouse Monoclonal Antibody (1B10)

ABT2014-1mL 1 mL
EUR 279
Description: Featured Anti-DDDDK Tag Mouse Monoclonal Antibody, Magnetic Beads, specially designed for immunoprecipitation (IP) of your tagged protein.

Magnetic Beads Conjugated Anti-DDDDK Tag Mouse Monoclonal Antibody (1B10)

ABT2014-5mL 5 mL
EUR 969
Description: Featured Anti-DDDDK Tag Mouse Monoclonal Antibody, Magnetic Beads, specially designed for immunoprecipitation (IP) of your tagged protein.

Anti-His Tag Antibody (Mouse IgG1)-coupled Magnetic Beads (recommended for MPCLIA)

MPC-A005 100mg
EUR 107
Description: The Anti-His Tag-coupled Magnetic Beads are 2.8 µm superparamagnetic particles covalently coupled to a highly affinity Polyclonal Rabbit anti-His Tag antibody. The beads can be used to capture the proteins containing N-terminal or C-terminal His Tags (6×His-10×His) in Chemiluminescence procedures. The Polyclonal Rabbit anti-His Tag antibodies are isolated as intact molecules from antisera by immunoaffinity chromatography.The Anti-His Tag-coupled Magnetic Beads is easy to capture his Tagged protein or other molecules, this ready to use products could greatly save your protein coupling time and hassle, and help us get the best performance and highly reproducible results.

Anti-His Tag Antibody, Human IgG1-coupled Magnetic Beads (recommended for MPCLIA)

MPC-A007 10mg
EUR 984.4
Description: The Anti-His Tag-coupled Magnetic Beads are 2.8 µm superparamagnetic particles covalently coupled to a highly affinity Monoclonal Anti-His Tag antibody. The beads can be used to capture the proteins containing C-terminal, N-terminal, and internal His tagged fusion in Chemiluminescence procedures. The Monoclonal Anti-His Tag antibody is a chimeric monoclonal antibody expressed from HEK293 cells, which combines the variable region of a mouse monoclonal antibody with human IgG1 constant domain. The Anti-His Tag-coupled Magnetic Beads is easy to capture his Tagged protein or other molecules, this ready to use products could greatly save your protein coupling time and hassle, and help us get the best performance and highly reproducible results.

VAMNE Magnetic Pathogen DNA/RNA Kit

RM601-01 50 rxns
EUR 144.8

CD9 Exo-Flow capture kit (Magnetic streptavidin beads, CD9-biotin capture antibody, Wash and Elution Buffers, Exo-FITC stain)

EXOFLOW100A-1 10 reactions
EUR 500

Circulating DNA Kit (with Magnetic Stand)

abx098869-50rxns 50 rxns
EUR 510

Circulating DNA Kit (with Magnetic Stand)

abx298026-50rxns 50 rxns
EUR 510

Basic Exo-Flow kit without any coupled antibodies (Uncoupled magnetic streptavidin beads, Wash and Elution Buffers, Exo-FITC stain)

CSFLOWBASICA-1 100 reactions
EUR 853

CD31 Exo-Flow capture kit (Magnetic streptavidin beads, CD31-biotin capture antibody, Wash and Elution Buffers, Exo-FITC stain)

EXOFLOW200A-1 10 reactions
EUR 500

CD44 Exo-Flow capture kit (Magnetic streptavidin beads, CD44-biotin capture antibody, Wash and Elution Buffers, Exo-FITC stain)

EXOFLOW210A-1 10 reactions
EUR 500

CD63 Exo-Flow capture kit (Magnetic streptavidin beads, CD63-biotin capture antibody, Wash and Elution Buffers, Exo-FITC stain)

EXOFLOW300A-1 10 reactions
EUR 500

CD81 Exo-Flow capture kit (Magnetic streptavidin beads, CD81-biotin capture antibody, Wash and Elution Buffers, Exo-FITC stain)

EXOFLOW400A-1 10 reactions
EUR 500

Rab5b Exo-Flow capture kit (Magnetic streptavidin beads, Rab5b-biotin capture antibody, Wash and Elution Buffers, Exo-FITC stain)

EXOFLOW500A-1 10 reactions
EUR 500

CD14 Exo-Flow capture kit (Magnetic streptavidin beads, CD14-biotin capture antibody, Wash and Elution Buffers, Exo-FITC stain)

EXOFLOW610A-1 10 reactions
EUR 500

CD68 Exo-Flow capture kit (Magnetic streptavidin beads, CD68-biotin capture antibody, Wash and Elution Buffers, Exo-FITC stain)

EXOFLOW620A-1 10 reactions
EUR 500

EpCAM Exo-Flow capture kit (Magnetic streptavidin beads, EpCAM-biotin capture antibody, Wash and Elution Buffers, Exo-FITC stain)

EXOFLOW630A-1 10 reactions
EUR 500

CD73 Exo-Flow capture kit (Magnetic streptavidin beads, CD73-biotin capture antibody, Wash and Elution Buffers, Exo-FITC stain)

EXOFLOW660A-1 10 reactions
EUR 500

Nickel NTA Magnetic Agarose Bead (5%)

MagNTANi5-10 10ml suspension
EUR 340.8

Nickel NTA Magnetic Agarose Bead (5%)

MagNTANi5-2 2ml suspension
EUR 118.8

Nickel NTA Magnetic Agarose Bead (5%)

MagNTANi5-5 5ml suspension
EUR 208.8

Viral DNA / RNA Kit (with Magnetic Stand)

abx098871-50rxns 50 rxns
EUR 477.6

Viral DNA/RNA Kit (with Magnetic Stand)

abx298029-50rxns 50 rxns
EUR 477.6

VAMNE Magnetic Pathogen DNA Kit (Prepackaged)

DM202-01 64 T
EUR 148.4

VAHTS DNA Clean Beads

N411-01 5 ml
EUR 259.2

VAHTS DNA Clean Beads

N411-02 60 ml
EUR 634.8

VAHTS DNA Clean Beads

N411-03 450 ml
EUR 3055.2

HLA-G Exo-Flow capture kit (Magnetic streptavidin beads, HLA-G-biotin capture antibody, Wash and Elution Buffers, Exo-FITC stain)

EXOFLOW600A-1 10 reactions
EUR 500

Blood Genomic DNA Kit (with Magnetic Stand)

abx098867-50rxns 50 rxns
EUR 360

Size Selection DNA Beads

20-abx298001
  • EUR 260.40
  • EUR 477.60
  • EUR 1663.20
  • 1 ml
  • 5 ml
  • 60 ml

VAMNE Magnetic Pathogen DNA/RNA Kit (Prepackaged)

RM602-01 64 T
EUR 185.6

Uracil DNA Glycosylase (UNG) Magnetic Luminex Assay Kit

LKU605001-96T 96T
EUR 966

Thymine DNA Glycosylase (TDG) Magnetic Luminex Assay Kit

LKU603892-96T 96T
EUR 966

Tetraspanin Exo-Flow Combo capture kit (Magnetic streptavidin beads, CD9, CD63, and CD81-biotin capture antibodies, Wash and Elution Buffers, Exo-FITC stain)

EXOFLOW150A-1 10 reactions
EUR 760

DNA Methyltransferase 1 (DNMT1) Magnetic Luminex Assay Kit

LKU606608-96T 96T
EUR 966

DNA Methyltransferase 1 (DNMT1) Magnetic Luminex Assay Kit

LKU606609-96T 96T
EUR 993.6

DNA Methyltransferase 1 (DNMT1) Magnetic Luminex Assay Kit

LKU606610-96T 96T
EUR 1048.8

IDA MagneZoom™ (Paramagnetic Beads)

20162010-1 -
EUR 118.04

IDA MagneZoom™ (Paramagnetic Beads)

20162010-2 -
EUR 319.37

GSH MagneZoom™ (Paramagnetic Beads)

20162020-1 -
EUR 176.4

GSH MagneZoom™ (Paramagnetic Beads)

20162020-2 -
EUR 364.83

DNA Methyltransferase 3A (DNMT3A) Magnetic Luminex Assay Kit

LKU606611-96T 96T
EUR 966

DNA Methyltransferase 3B (DNMT3B) Magnetic Luminex Assay Kit

LKU606612-96T 96T
EUR 993.6

DNA Methyltransferase 3B (DNMT3B) Magnetic Luminex Assay Kit

LKU606613-96T 96T
EUR 966

COOH MagneZoom™ (Paramagnetic Beads)

20162008-1 -
EUR 226.02

COOH MagneZoom™ (Paramagnetic Beads)

20162008-2 -
EUR 303.23

DNA Repair Protein RAD50 (RAD50) Magnetic Luminex Assay Kit

LKU606619-96T 96T
EUR 993.6

DNA Repair Protein RAD50 (RAD50) Magnetic Luminex Assay Kit

LKU606620-96T 96T
EUR 966

MagneZoom™ (Paramagnetic Beads) Station

20160000-1 -
EUR 83.35

MagneZoom™ (Paramagnetic Beads) Station

20160000-2 -
EUR 116.22

MagneZoom™ (Paramagnetic Beads) Control

20162011-1 -
EUR 42.68

MagneZoom™ (Paramagnetic Beads) Control

20162011-2 -
EUR 63.86

Polymerase DNA Directed Beta (POLb) Magnetic Luminex Assay Kit

LKU606621-96T 96T
EUR 966

We subsequently screened a human Area Antibody library in opposition to CSF114(Glc) utilizing magnetic separation as a panning methodology. We obtained and described a number of clones, and the one with the very best indicators was produced as a 6×His-tagged protein to correctly examine the binding properties as a soluble antibody.

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